Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:18Z
Fecha de publicación2010-01-01
ResumenLeptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ +45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p = 0.01 for G/A genotype and p = 0.02 for the recessive model G/G + G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.es_ES
Doihttps://doi.org/10.3233/cbm-2010-0154es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5126
Idiomaenes_ES
EditorialIOS PRESSes_ES
RelaciónCancer Biomarkerses_ES
URL relacionadohttps://doi.org/10.3233/cbm-2010-0154es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCancer Biomarkers
Palabra claveLeptines_ES
Palabra claveadiponectines_ES
Palabra clavecolorectal canceres_ES
Palabra clavepolymorphismes_ES
TítuloAssociation of LEP and ADIPOQ common variants with colorectal cancer in Mexican patientses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPartida-Perez, Miriam
Autorde la Luz Ayala-Madrigal, Maria
AutorPeregrina-Sandoval, Jorge
AutorMacias-Gomez, Nelly
AutorMoreno-Ortiz, Jose
AutorLeal-Ugarte, Evelia
AutorCardenas-Meza, Mario
AutorCenteno-Flores, Manuel
AutorMaciel-Gutierrez, Victor
AutorCabrales, Enrique
AutorCervantes-Ortiz, Sergio
AutorGutierrez-Angulo, Melva
AutorPartida-Perez, Miriames_ES
Autorde la Luz Ayala-Madrigal, Mariaes_ES
AutorPeregrina-Sandoval, Jorgees_ES
AutorMacias-Gomez, Nellyes_ES
AutorMoreno-Ortiz, Josees_ES
AutorLeal-Ugarte, Eveliaes_ES
AutorCardenas-Meza, Marioes_ES
AutorCenteno-Flores, Manueles_ES
AutorMaciel-Gutierrez, Victores_ES
AutorCabrales, Enriquees_ES
AutorCervantes-Ortiz, Sergioes_ES
AutorGutierrez-Angulo, Melvaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas117-121es_ES
URL relacionadahttps://doi.org/10.3233/cbm-2010-0154
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen7es_ES

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