Relationship Between Blood Levels and the Anti‐Hyperalgesic Effect of Ketoprofen in the Rat

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:16Z
Fecha de publicación2014-01-01
ResumenAbstract Preclinical Research The relationship between blood levels of ketoprofen and its anti‐hyperalgesic effects was examined in rat using the carrageenan‐evoked thermal hyperalgesia model. Female adult Wistar rats were injected with carrageenan into the plantar surface of the right hind paw. Immediately after, rats were administered with ketoprofen po and hindpaw withdrawal latency measured and micro‐whole blood samples were obtained over six hours via a cannula inserted in the caudal artery. Ketoprofen levels were measured by HPLC. Ketoprofen concentration increased in a dose‐dependent manner and was reflected in dose‐dependent anti‐hyperalgesic effect. The pharmacokinetic and pharmacodynamic parameters expressed as mean ± s.e.m. following administration of 1, 3.2, and 10 mg/kg ketoprofen were: Cmax 1.27 ± 0.08, 3.44 ± 0.20 and 11.76 ± 0.81 μg/mL; AUClast 4.16 ± 0.17, 11.63 ± 0.65 and 28.15 ± 1.32 μg h/mL; and Emax observed (AUCE): 65.41 ± 7.79, 92.06 ± 6.46 and 98.42 ± 7.53%. A direct relationship between blood concentrations and the anti‐hyperalgesic effect of ketoprofen followed a maximum effect model equation. The results indicate that the anti‐hyperalgesic effect of ketoprofen in the carrageenan pain model can be predicted by the pharmacokinetic properties of ketoprofen.es_ES
Doihttps://doi.org/10.1002/ddr.21167es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2234
Idiomaeses_ES
EditorialWileyes_ES
RelaciónDrug Development Researches_ES
URL relacionadohttps://doi.org/10.1002/ddr.21167es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteDrug Development Research
TítuloRelationship Between Blood Levels and the Anti‐Hyperalgesic Effect of Ketoprofen in the Rates_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAguilar‐Carrasco, José Carlos
AutorRodríguez‐Silverio, Juan
AutorJiménez‐Andrade, Juan Miguel
AutorCarrasco‐Portugal, Miriam del Carmen
AutorFlores‐Murrieta, Francisco Javier
AutorAguilar‐Carrasco, José Carloses_ES
AutorRodríguez‐Silverio, Juanes_ES
AutorJiménez‐Andrade, Juan Migueles_ES
AutorCarrasco‐Portugal, Miriam del Carmenes_ES
AutorFlores‐Murrieta, Francisco Javieres_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas189-194es_ES
URL relacionadahttps://doi.org/10.1002/ddr.21167
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen75es_ES

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