New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:33Z
Fecha de publicación2021-01-01
ResumenVisceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver disease (NAFLD). NAFLD is a common cause of abnormal liver function, and numerous studies have established the enormously deleterious role of hepatic steatosis in ischemia-reperfusion (I/R) injury that inevitably occurs in both liver resection and transplantation. Thus, steatotic livers exhibit a higher frequency of post-surgical complications after hepatectomy, and using liver grafts from donors with NAFLD is associated with an increased risk of post-surgical morbidity and mortality in the recipient. Diabetes, another MetS-related metabolic disorder, also worsens hepatic I/R injury, and similar to NAFLD, diabetes is associated with a poor prognosis after liver surgery. Due to the large increase in the prevalence of MetS, NAFLD, and diabetes, their association is frequent in the population and therefore, in patients requiring liver resection and in potential liver graft donors. This scenario requires advancement in therapies to improve postoperative results in patients suffering from metabolic diseases and undergoing liver surgery; and in this sense, the bases for designing therapeutic strategies are in-depth knowledge about the molecular signaling pathways underlying the effects of MetS-related diseases and I/R injury on liver tissue. A common denominator in all these diseases is autophagy. In fact, in the context of obesity, autophagy is profoundly diminished in hepatocytes and alters mitochondrial functions in the liver. In insulin resistance conditions, there is a suppression of autophagy in the liver, which is associated with the accumulation of lipids, being this is a risk factor for NAFLD. Also, oxidative stress occurring in hepatic I/R injury promotes autophagy. The present review aims to shed some light on the role of autophagy in livers undergoing surgery and also suffering from metabolic diseases, which may lead to the discovery of effective therapeutic targets that could be translated from laboratory to clinical practice, to improve postoperative results of liver surgeries when performed in the presence of one or more metabolic diseases.es_ES
Doihttps://doi.org/10.3389/fcell.2021.670273es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5367
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Cell and Developmental Biologyes_ES
URL relacionadohttps://doi.org/10.3389/fcell.2021.670273es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Cell and Developmental Biology
Palabra claveautophagyes_ES
Palabra clavemetabolic syndromees_ES
Palabra claveischemia-reperfusiones_ES
Palabra claveliver surgeryes_ES
Palabra clavetransplantationes_ES
TítuloNew Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseaseses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlvarez-Mercado, Ana Isabel
AutorRojano-Alfonso, Carlos
AutorMico-Carnero, Marc
AutorCaballeria-Casals, Albert
AutorPeralta, Carmen
AutorCasillas-Ramirez, Arani
AutorAlvarez-Mercado, Ana Isabeles_ES
AutorRojano-Alfonso, Carloses_ES
AutorMico-Carnero, Marces_ES
AutorCaballeria-Casals, Albertes_ES
AutorPeralta, Carmenes_ES
AutorCasillas-Ramirez, Aranies_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fcell.2021.670273
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

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