Brain-derived neurotrophic factor expression in granulosa lutein cells
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-10-05T16:33:06Z | |
| Fecha de publicación | 2011-01-01 | |
| Resumen | Brain-derived neurotrophic factor (BDNF) is thought to play a role in follicle activation and oocyte maturation. It is postulated that BDNF and its receptor, tyrosine kinase receptor B (TrkB), may also play a role in maintaining the corpus luteum. Therefore, human granulosa lutein cells (GLC) were obtained from women undergoing ovulation induction and treated with increasing concentrations of cAMP (0, 125, 500 and 1000 mu mol/l). BDNF and progesterone concentrations were quantified by enzyme-linked immunosorbent assay. cAMP treatment significantly increased progesterone output but had no effect on BDNF concentration in the spent media. However, the BDNF concentration was significantly increased in GLC lysates. To assess the expression of BDNF and TrkB in active versus regressing corpora lutea, ovaries from adult female BALBc mice (n = 4) from each day of the oestrous cycle were processed for immunohistochemistry. Two markers of luteal activity were used (3 beta-hydroxysteroid dehydrogenase and tenascin-X). There was a trend towards higher BDNF and TrkB H-scores in active versus regressing corpus lutea. In conclusion, intracellular BNDF concentrations were dose-dependently increased by cAMP but treatments had no effect on BDNF output. It is speculated that BDNF contributes in an autocrine manner to GLC survival in the active corpus luteum. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | es_ES |
| Doi | https://doi.org/10.1016/j.rbmo.2010.09.001 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/4909 | |
| Idioma | en | es_ES |
| Editorial | ELSEVIER SCI LTD | es_ES |
| Relación | Reproductive BioMedicine Online | es_ES |
| URL relacionado | https://doi.org/10.1016/j.rbmo.2010.09.001 | es_ES |
| Derechos | Acceso abierto (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_abf2 | es_ES |
| Fuente | Reproductive BioMedicine Online | |
| Palabra clave | 3 beta-HSD | es_ES |
| Palabra clave | BDNF | es_ES |
| Palabra clave | corpus luteum | es_ES |
| Palabra clave | neurotrophins | es_ES |
| Palabra clave | ovary | es_ES |
| Título | Brain-derived neurotrophic factor expression in granulosa lutein cells | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | Dominguez, Miguel A. | |
| Autor | Cho, Natalie | |
| Autor | Zhang, Bingjun | |
| Autor | Neal, Michael S. | |
| Autor | Foster, Warren G. | |
| Autor | Dominguez, Miguel A. | es_ES |
| Autor | Cho, Natalie | es_ES |
| Autor | Zhang, Bingjun | es_ES |
| Autor | Neal, Michael S. | es_ES |
| Autor | Foster, Warren G. | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Número | 1 | es_ES |
| Rango de páginas | 17-24 | es_ES |
| URL relacionada | https://doi.org/10.1016/j.rbmo.2010.09.001 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 22 | es_ES |