Influence of adiposity and sex on SARS-CoV-2 antibody response in vaccinated university students: A cross-sectional ESFUERSO study

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2024-01-01
ResumenPrior studies have identified various determinants of differential immune responses to COVID19. This study focused on the Ig-G anti-RBD marker, analyzing its potential correlations with sex, vaccine type, body fat percentage, metabolic risk, perceived stress, and previous COVID19 exposure. In this study, data (available in S1 Data) were obtained from 108 participants from the ESFUERSO cohort, who completed questionnaires detailing their COVID-19 experiences and stress levels assessed through the SISCO scale. IgG anti-RBD concentrations were quantified using an ELISA assay developed by UNAM. Multiple regression analysis was employed to control for covariates, including sex, age, body fat percentage, body mass index (BMI), and perceived stress. This sample comprised young individuals (average age of 21.4 years), primarily consisting of females (70\%), with a substantial proportion reporting a family history of diabetes, hypertension, or obesity. Most students had received the Moderna or Pfizer vaccines, and 91\% displayed a positive anti-RBD response. A noteworthy finding was the interaction between body fat percentage and sex. In males, increased adiposity was associated with decreased Ig-G anti-RBD concentration; in females, the response increased. Importantly, this pattern remained consistent regardless of the vaccine received. No significant associations of sex and body fat percentage on the immune response through Ig-G anti-RBD levels to COVID-19 vaccines. The implications of these findings offer a foundation for educational initiatives and the formulation of preventive policies aimed at mitigating health disparities.es_ES
Doihttps://doi.org/10.1371/journal.pgph.0002686es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5447
Idiomaenes_ES
EditorialPUBLIC LIBRARY SCIENCEes_ES
RelaciónPLOS Global Public Healthes_ES
URL relacionadohttps://doi.org/10.1371/journal.pgph.0002686es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuentePLOS Global Public Health
TítuloInfluence of adiposity and sex on SARS-CoV-2 antibody response in vaccinated university students: A cross-sectional ESFUERSO studyes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPerales-Torres, Adriana L.
AutorPerez-Navarro, Lucia M.
AutorGarcia-Oropesa, Esperanza M.
AutorDiaz-Badillo, Alvaro
AutorMartinez-Lopez, Yoscelina Estrella
AutorRosas, Marisol
AutorCastillo, Octelina
AutorRamirez-Quintanilla, Laura
AutorCervantes, Jacquelynne
AutorSciutto, Edda
AutorCisneros, Claudia X. Munguia
AutorRamirez-Pfeiffer, Carlos
AutorVela, Leonel
AutorTapia, Beatriz
AutorLopez-Alvarenga, Juan C.
AutorPerales-Torres, Adriana L.es_ES
AutorPerez-Navarro, Lucia M.es_ES
AutorGarcia-Oropesa, Esperanza M.es_ES
AutorDiaz-Badillo, Alvaroes_ES
AutorMartinez-Lopez, Yoscelina Estrellaes_ES
AutorRosas, Marisoles_ES
AutorCastillo, Octelinaes_ES
AutorRamirez-Quintanilla, Lauraes_ES
AutorCervantes, Jacquelynnees_ES
AutorSciutto, Eddaes_ES
AutorCisneros, Claudia X. Munguiaes_ES
AutorRamirez-Pfeiffer, Carloses_ES
AutorVela, Leoneles_ES
AutorTapia, Beatrizes_ES
AutorLopez-Alvarenga, Juan C.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
URL relacionadahttps://doi.org/10.1371/journal.pgph.0002686
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen4es_ES

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