Effectiveness of topical phenytoin therapy versus platelet-rich plasma for tympanic perforations closure: Comparative study

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:19Z
Fecha de publicación2016-01-01
ResumenBackground: The tympanic membrane perforation is generally caused by infection or trauma. It is a condition that can cause hearing loss; its incidence varies between 1 and 3% of the population in the United States, and even less than 1% in the world population. Objective: This study is to conduct a pilot test in which the effectiveness of conservative treatment was measured and compared by applying phenytoin or platelet-rich plasma to close tympanic perforations and the healing period of the same. Patients and methods: Ten patients were included and all of them fulfilled the selection criteria: Age over five years-old, indiscriminate sex with a diagnosis of perforated eardrum, eardrum perforation between 30 and 60% and presence of tympanic remnant; and no previous surgical treatment. Elimination criteria were those patients with marginal eardrum perforations, patients who were not on antiplatelet drugs or anticoagulants, poor response to platelet-rich plasma after 6 weeks, patients with known autoimmune, active neoplastic, atopic otic conditions and those currently under immunosuppressive treatments. Participants were randomized into two groups according to treatment: phenytoin (0.2 mg) or platelet-rich plasma (0.2-0.5 cc). Results: Ten patients with unilateral tympanic perforation were recorded whose average age was 26.9 ± 14.9 years; the sex distribution was 1.5:1 male predominance. In treatment A, the average closing time was 3.8 ± 0.836 weeks; meanwhile, in the treatment B the closure time was 5.2 ± 0.836 weeks.es_ES
Doihttps://doi.org/10.1016/j.hgmx.2016.05.006es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6103
Idiomaenes_ES
EditorialElsevier Doymaes_ES
RelaciónRevista Medica del Hospital General de Mexicoes_ES
URL relacionadohttps://doi.org/10.1016/j.hgmx.2016.05.006es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteRevista Medica del Hospital General de Mexico
Palabra clavePerforated eardrumes_ES
Palabra clavePhenytoines_ES
Palabra clavePlatelet rich plasmaes_ES
TítuloEffectiveness of topical phenytoin therapy versus platelet-rich plasma for tympanic perforations closure: Comparative studyes_ES
Título alternativoEficacia de la terapia tópica de fenitoína versus el plasma rico en plaquetas para el cierre de perforaciones timpánicas: Estudio comparativoes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autorde Oca, A. Ayala-Montes
AutorAlla, S.N.
AutorLópez-Valdés, J.C.
Autorde Oca, A. Ayala-Monteses_ES
AutorAlla, S.N.es_ES
AutorLópez-Valdés, J.C.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas183-188es_ES
URL relacionadahttps://doi.org/10.1016/j.hgmx.2016.05.006
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen79es_ES

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