Association of the 5HTTLPR Polymorphism with Obesity in Mexican Women with High Native American Ancestry

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:05Z
Fecha de publicación2020-10-14
ResumenAims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L- and S-alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) groups; 40 Mexican mestizos; and 33 Caucasian Mennonites were enrolled in a cross-sectional study. High (≥90%) and low (<90%) NA ancestry was molecularly determined. A body mass index >30 kg/m 2 was considered as obese. The L- and S-alleles of the 5HTTLPR locus were identified by PCR; the association between alleles and obesity was performed by logistic regression analysis. Results: A significantly lower prevalence of obesity (35%) was observed in participants from communities with high NA ancestry ( p < 0.005). Under a dominant heritance model the L-allele was associated with obesity in women with high NA ancestry (odds ratio [OR] 7.27; 95% confidence interval [CI] 1.6-32.5; p = 0.009) but not in women with low NA ancestry (OR 0.83; 95% CI 0.3-2.2; p = 0.71); no association was observed in men. Conclusion: Our results suggest that the 5HTTLPR L-allele is a risk factor for developing obesity in Mexican women with high NA ancestry (≥90%).es_ES
Doihttps://doi.org/10.1089/gtmb.2020.0068es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2768
Idiomaenes_ES
EditorialMary Ann Liebert, Inc.es_ES
RelaciónGenetic Testing and Molecular Biomarkerses_ES
URL relacionadohttps://doi.org/10.1089/gtmb.2020.0068es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteGenetic Testing and Molecular Biomarkers
Palabra claveObesityes_ES
Palabra claveOdds ratioes_ES
Palabra claveConfidence intervales_ES
Palabra claveBody mass indexes_ES
Palabra claveAllelees_ES
Palabra claveMedicinees_ES
Palabra claveLogistic regressiones_ES
Palabra claveIndigenouses_ES
Palabra claveGenotypees_ES
Palabra claveCross-sectional studyes_ES
Palabra claveDemographyes_ES
Palabra claveInternal medicinees_ES
ClasificaciónGenetic Associations and Epidemiologyes_ES
TítuloAssociation of the 5HTTLPR Polymorphism with Obesity in Mexican Women with High Native American Ancestryes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGalavíz-Hernández, Carlos
AutorLazalde-Ramos, Blanca Patricia
AutorMartínez-Cortés, G.
AutorRangel‐Villalobos, Héctor
AutorMartínez‐Aguilar, Gerardo
AutorLeal‐Ugarte, Evelia
AutorPeralta-Leal, Valeria
AutorGonzález‐Renteria, Siblie Marbey
AutorRodríguez‐Morán, Martha
AutorJaquez-Chairez, Francia O
AutorGuerrero‐Romero, Fernando
AutorSosa‐Macías, Martha
AutorGalavíz-Hernández, Carloses_ES
AutorLazalde-Ramos, Blanca Patriciaes_ES
AutorMartínez-Cortés, G.es_ES
AutorRangel‐Villalobos, Héctores_ES
AutorMartínez‐Aguilar, Gerardoes_ES
AutorLeal‐Ugarte, Eveliaes_ES
AutorPeralta-Leal, Valeriaes_ES
AutorGonzález‐Renteria, Siblie Marbeyes_ES
AutorRodríguez‐Morán, Marthaes_ES
AutorJaquez-Chairez, Francia Oes_ES
AutorGuerrero‐Romero, Fernandoes_ES
AutorSosa‐Macías, Marthaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número11es_ES
Rango de páginas754-758es_ES
URL relacionadahttps://doi.org/10.1089/gtmb.2020.0068
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen24es_ES

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