Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B-annulatus and B-microplus infestations

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:39Z
Fecha de publicación2009-01-01
ResumenBackground: The cattle ticks, Boophilus spp., affect cattle production in tropical and subtropical regions of the world. Tick vaccines constitute a cost-effective and environmentally friendly alternative to tick control. The recombinant B. microplus Bm86 protective antigen has been shown to protect cattle against tick infestations. Recently, the gene coding for B. annulatus Bm86 ortholog, Ba86, was cloned and the recombinant protein was secreted and purified from the yeast Pichia pastoris. Results: Recombinant Ba86 (Israel strain) was used to immunize cattle to test its efficacy for the control of B. annulatus (Mercedes, Texas, USA strain) and B. microplus (Susceptible, Mexico strain) infestations. Bm86 (Gavac and Mozambique strain) and adjuvant/saline were used as positive and negative controls, respectively. Vaccination with Ba86 reduced tick infestations (71\% and 40\%), weight (8\% and 15\%), oviposition (22\% and 5\%) and egg fertility (25\% and 50\%) for B. annulatus and B. microplus, respectively. The efficacy of both Ba86 and Bm86 was higher for B. annulatus than for B. microplus. The efficacy of Ba86 was higher for B. annulatus (83.0\%) than for B. microplus (71.5\%). The efficacy of Bm86 (Gavac; 85.2\%) but not Bm86 (Mozambique strain; 70.4\%) was higher than that of Ba86 (71.5\%) on B. microplus. However, the efficacy of Bm86 (both Gavac and Mozambique strain; 99.6\%) was higher than that of Ba86 (83.0\%) on B. annulatus. Conclusion: These experiments showed the efficacy of recombinant Ba86 for the control of B. annulatus and B. microplus infestations in cattle and suggested that physiological differences between B. microplus and B. annulatus and those encoded in the sequence of Bm86 orthologs may be responsible for the differences in susceptibility of these tick species to Bm86 vaccines.es_ES
Doihttps://doi.org/10.1186/1472-6750-9-29es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5461
Idiomaenes_ES
EditorialBMCes_ES
RelaciónBMC Biotechnologyes_ES
URL relacionadohttps://doi.org/10.1186/1472-6750-9-29es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBMC Biotechnology
TítuloVaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B-annulatus and B-microplus infestationses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCanales, Mario
AutorAlmazan, Consuelo
AutorNaranjo, Victoria
AutorJongejan, Frans
Autorde la Fuente, Jose
AutorCanales, Marioes_ES
AutorAlmazan, Consueloes_ES
AutorNaranjo, Victoriaes_ES
AutorJongejan, Franses_ES
Autorde la Fuente, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.1186/1472-6750-9-29
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

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