The Role of Neuregulin-1 in Steatotic and Non-Steatotic Liver Transplantation from Brain-Dead Donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:08Z
Fecha de publicación2022-01-01
ResumenBackground. Brain death (BD) and steatosis are key risk factors to predict adverse post-transplant outcomes. We investigated the role of Neuregulin-1 (NRG1) in rat steatotic and nonsteatotic liver transplantation (LT) from brain death donors (DBD). Methods: NRG1 pathways were characterized after surgery. Results: NRG1 and p21-activated kinase 1 (PAK1) levels increased in steatotic and non-steatotic grafts from DBDs. The abolishment of NRG1 effects reduced PAK1. When the effect of either NRG1 nor PAK1 was inhibited, injury and regenerative failure were exacerbated. The benefits of the NRG-1-PAK1 axis in liver grafts from DBDs were associated with increased vascular endothelial growth factor-A (VEGFA) and insulin growth factor-1 (IGF1) levels, respectively. Indeed, VEGFA administration in non-steatotic livers and IGF1 treatment in steatotic grafts prevented damage and regenerative failure resulting from the inhibition of either NRG1 or PAK-1 activity in each type of liver. Exogenous NRG1 induced greater injury than BD induction. Conclusions: This study indicates the benefits of endogenous NRG1 in liver grafts from DBDs and underscores the specificity of the NRG1 signaling pathway depending on the type of liver: NRG1-PAK1-VEGFA in non-steatotic livers and NRG1-PAK1-IGF1 in steatotic livers. Exogenous NRG1 is not an appropriate strategy to apply to liver grafts from DBD.es_ES
Doihttps://doi.org/10.3390/biomedicines10050978es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4983
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónBiomedicineses_ES
URL relacionadohttps://doi.org/10.3390/biomedicines10050978es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBiomedicines
Palabra claveneuregulin-1es_ES
Palabra clavebrain deathes_ES
Palabra claveliver transplantationes_ES
Palabra clavesteatotic liver graftses_ES
Palabra claveischemia-reperfusiones_ES
TítuloThe Role of Neuregulin-1 in Steatotic and Non-Steatotic Liver Transplantation from Brain-Dead Donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMico-Carnero, Marc
AutorCasillas-Ramirez, Arani
AutorSanchez-Gonzalez, Alfredo
AutorRojano-Alfonso, Carlos
AutorPeralta, Carmen
AutorMico-Carnero, Marces_ES
AutorCasillas-Ramirez, Aranies_ES
AutorSanchez-Gonzalez, Alfredoes_ES
AutorRojano-Alfonso, Carloses_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
URL relacionadahttps://doi.org/10.3390/biomedicines10050978
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

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