Differential Role of Type 2 Diabetes as a Risk Factor for Tuberculosis in the Elderly versus Younger Adults

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:59Z
Fecha de publicación2022-01-01
ResumenThe elderly are understudied despite their high risk of tuberculosis (TB). We sought to identify factors underlying the lack of an association between TB and type 2 diabetes (T2D) in the elderly, but not adults. We conducted a case–control study in elderly (≥65 years old; ELD) vs. younger adults (young/middle-aged adults (18–44/45–64 years old; YA|MAA) stratified by TB and T2D, using a research study population (n = 1160) and TB surveillance data (n = 8783). In the research study population the adjusted odds ratio (AOR) of TB in T2D was highest in young adults (AOR 6.48) but waned with age becoming non-significant in the elderly. Findings were validated using TB surveillance data. T2D in the elderly (vs. T2D in younger individuals) was characterized by better glucose control (e.g., lower hyperglycemia or HbA1c), lower insulin resistance, more sulphonylureas use, and features of less inflammation (e.g., lower obesity, neutrophils, platelets, anti-inflammatory use). We posit that differences underlying glucose dysregulation and inflammation in elderly vs. younger adults with T2D, contribute to their differential association with TB. Studies in the elderly provide valuable insights into TB-T2D pathogenesis, e.g., here we identified insulin resistance as a novel candidate mechanism by which T2D may increase active TB risk.es_ES
Doihttps://doi.org/10.3390/pathogens11121551es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5757
Idiomaenes_ES
EditorialMultidisciplinary Digital Publishing Institute (MDPI)es_ES
RelaciónPathogenses_ES
URL relacionadohttps://doi.org/10.3390/pathogens11121551es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuentePathogens
Palabra clavediabeteses_ES
Palabra claveelderlyes_ES
Palabra clavehyperglycemiaes_ES
Palabra claveinflammationes_ES
Palabra claveinsulin resistancees_ES
Palabra claveNSAIDes_ES
Palabra clavetuberculosises_ES
TítuloDifferential Role of Type 2 Diabetes as a Risk Factor for Tuberculosis in the Elderly versus Younger Adultses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRestrepo, Blanca I.
AutorScordo, Julia M.
AutorAguillón-Durán, Génesis P.
AutorAyala, Doris
AutorQuirino-Cerrillo, Ana Paulina
AutorLoera-Salazar, Raúl
AutorCruz-González, America
AutorCaso, Jose A.
AutorJoya-Ayala, Mateo
AutorGarcía-Oropesa, Esperanza M.
AutorSalinas, Alejandra B.
AutorMartinez, Leonardo
AutorSchlesinger, Larry S.
AutorTorrelles, Jordi B.
AutorTurner, Joanne
AutorRestrepo, Blanca I.es_ES
AutorScordo, Julia M.es_ES
AutorAguillón-Durán, Génesis P.es_ES
AutorAyala, Dorises_ES
AutorQuirino-Cerrillo, Ana Paulinaes_ES
AutorLoera-Salazar, Raúles_ES
AutorCruz-González, Americaes_ES
AutorCaso, Jose A.es_ES
AutorJoya-Ayala, Mateoes_ES
AutorGarcía-Oropesa, Esperanza M.es_ES
AutorSalinas, Alejandra B.es_ES
AutorMartinez, Leonardoes_ES
AutorSchlesinger, Larry S.es_ES
AutorTorrelles, Jordi B.es_ES
AutorTurner, Joannees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número12es_ES
URL relacionadahttps://doi.org/10.3390/pathogens11121551
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen11es_ES

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