Role of FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde?

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2021-01-01
ResumenThe pro-tumorigenic activity of fibroblast growth factor (FGF) 19 (FGF15 in its rodent orthologue) in hepatocellular carcinoma (HCC), as well as the unsolved problem that ischemia-reperfusion (IR) injury supposes in liver surgeries, are well known. However, it has been shown that FGF15 administration protects against liver damage and regenerative failure in liver transplantation (LT) from brain-dead donors without tumor signals, providing a benefit in avoiding IR injury. The protection provided by FGF15/19 is due to its anti-apoptotic and pro-regenerative properties, which make this molecule a potentially beneficial or harmful factor, depending on the disease. In the present review, we describe the preclinical models currently available to understand the signaling pathways responsible for the apparent controversial effects of FGF15/19 in the liver (to repair a damaged liver or to promote tumorigenesis). As well, we study the potential pharmacological use that has the activation or inhibition of FGF15/19 pathways depending on the disease to be treated. We also discuss whether FGF15/19 non-pro-tumorigenic variants, which have been developed for the treatment of liver diseases, might be promising approaches in the surgery of hepatic resections and LT using healthy livers and livers from extended-criteria donors.es_ES
Doihttps://doi.org/10.3390/cells10061421es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5432
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónCellses_ES
URL relacionadohttps://doi.org/10.3390/cells10061421es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCells
Palabra clavehepatocellular carcinomaes_ES
Palabra claveliver transplantationes_ES
Palabra claveischemia-reperfusion injuryes_ES
Palabra claveliver surgeryes_ES
Palabra clavefibroblast growth factores_ES
TítuloRole of FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde?es_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCaballeria-Casals, Albert
AutorMico-Carnero, Marc
AutorRojano-Alfonso, Carlos
AutorMaroto-Serrat, Cristina
AutorCasillas-Ramirez, Arani
AutorAlvarez-Mercado, Ana I.
AutorGracia-Sancho, Jordi
AutorPeralta, Carmen
AutorCaballeria-Casals, Albertes_ES
AutorMico-Carnero, Marces_ES
AutorRojano-Alfonso, Carloses_ES
AutorMaroto-Serrat, Cristinaes_ES
AutorCasillas-Ramirez, Aranies_ES
AutorAlvarez-Mercado, Ana I.es_ES
AutorGracia-Sancho, Jordies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número6es_ES
URL relacionadahttps://doi.org/10.3390/cells10061421
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

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