Expression of perilipin in human promyelocytic cells in response to Anaplasma phagocytophilum infection results in modified lipid metabolism

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:50Z
Fecha de publicación2008-01-01
ResumenThe obligate intracellular pathogen Anaplasma phagocytophilum is transmitted by ticks and causes human granulocytic anaplasmosis, tick-borne fever of ruminants, and equine and canine granulocytic anaplasmosis. In a previous study, the perilipin (PLIN) gene was identified as one of the genes differentially expressed in human promyelocytic HL-60 cells in response to infection with A. phagocytophilum. PLIN is a major adipocyte lipid droplet-associated phosphoprotein that plays a central role in lipolysis and cholesterol synthesis. Host cholesterol and other lipids are required by A. phagocytophilum for infection and multiplication in human cells. In this study, it was hypothesized that PLIN may be involved in infection of human HL-60 cells by A. phagocytophilum. To test this hypothesis, a combination of real-time RT-PCR, immunofluorescence and RNA interference was used to study the expression of PLIN. The results of these studies demonstrated that A. phagocytophilum modulates lipid metabolism by increasing PLIN mRNA levels and facilitates infection of HL-60 cells. The results of these studies expand our knowledge of the role of lipid metabolism in A. phagocytophilum infection and multiplication in HL-60 cells and suggest a mechanism by which A. phagocytophilum modulates lipid metabolism.es_ES
Doihttps://doi.org/10.1099/jmm.0.47504-0es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1799
Idiomaeses_ES
EditorialMicrobiology Societyes_ES
RelaciónJournal of Medical Microbiologyes_ES
URL relacionadohttps://doi.org/10.1099/jmm.0.47504-0es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Medical Microbiology
TítuloExpression of perilipin in human promyelocytic cells in response to Anaplasma phagocytophilum infection results in modified lipid metabolismes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorManzano-Roman, Raúl
AutorAlmazán, Consuelo
AutorNaranjo, Victoria
AutorBloui, Edmour F.
AutorKocan, Katherine M.
AutorFuente, José de la
AutorManzano-Roman, Raúles_ES
AutorAlmazán, Consueloes_ES
AutorNaranjo, Victoriaes_ES
AutorBloui, Edmour F.es_ES
AutorKocan, Katherine M.es_ES
AutorFuente, José de laes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas159-163es_ES
URL relacionadahttps://doi.org/10.1099/jmm.0.47504-0
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen57es_ES

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