TYMS 2R3R polymorphism and DPYD {[}IVS] 14+1G>A gene mutation in Mexican colorectal cancer patients

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AudienciaPúblico en generales_ES
CoberturaMéxico[ 143]es_ES
Fecha de ingreso2026-10-05T16:34:49Z
Fecha de publicación2018-01-01
ResumenObjective: To examine the association between TYMS 2R3R polymorphism and DPYD {[}IVS]14+1G>A mutation by comparing healthy subjects with colorectal cancer (CRC) patients in the Mexican population. Method: Genotyping of the 2R/3R was performed by polymerase chain reaction (PCR) and {[}IVS]14+1G>A mutation by real-time PCR analysis. Results: The observed frequencies of the TYMS 2R3R polymorphism and the -{[}IVS]14+1G>A mutation in DPYD did not indicate an increased risk for CRC (p>0.05). However we observed an association of the 2R/2R (OR 3.08, 95\% CI 1.66-6.08, p=0.0017) and heterozygous (OR 1.98, 95\% CI 1.32-2.97, p=0.0012) genotypes as risk factors when comparing controls and CRC patients that were also tobacco consumers. An association between the genotype and the disease was evident. The distribution of the 2R/2R genotype and hematological toxicity (adjusted OR 2.26, 95\% CI 1.54-4.45, p=0.0259), heterozygous (2R/3R) with tumor stage III-IV (OR 1.81, 95\% CI 1.11-2.94, p=0.020) and 2R/2R-2R/3R in non-chemotherapy response CRC patients with hematological (OR 2.3, 95\% CI 1.21-4.4, p=0.014) and gastric toxicities (OR 3.11, 95\% CI 1.18-8.2, p=0.035) confirmed that this factor may significantly contribute to the CRC susceptibility. Conclusion: TYMS 2R3R polymorphism and the -{[}IVS] 14+1G>A mutation in DPYD was not associated with susceptibility to CRC. However, the 2R/2R and 2R/3R genotypes of TYMS polymorphism could significantly contribute to hematological and gastric toxicity in CRC patients in this sample population.es_ES
Doihttps://doi.org/10.18388/abp.2017\_2338es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6305
IdiomaInglés[20]es_ES
EditorialACTA BIOCHIMICA POLONICAes_ES
RelaciónActa Biochimica Polonicaes_ES
URL relacionadohttps://doi.org/10.18388/abp.2017\_2338es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteActa Biochimica Polonica
Palabra claveTYMS 2R/3Res_ES
Palabra clavecolorectal canceres_ES
Palabra clavepolymorphismes_ES
Palabra claveDPYD {[}IVS] 14+1G>Aes_ES
Palabra claveMexican populationes_ES
TítuloTYMS 2R3R polymorphism and DPYD {[}IVS] 14+1G>A gene mutation in Mexican colorectal cancer patientses_ES
TipoPonenciaes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPatricia Gallegos-Arreola, Martha
AutorMoises Zuniga-Gonzalez, Guillermo
AutorYoaly Sanchez-Lopez, Josefina
AutorNaranjo Cruz, Alondra Yeraldi
AutorPeralta-Leal, Valeria
AutorEduardo Figuera, Luis
AutorMaria Puebla-Perez, Ana
AutorAlberto Ronquillo-Carreon, Carlos
AutorGraciela Puebla-Mora, Ana
AutorPatricia Gallegos-Arreola, Marthaes_ES
AutorMoises Zuniga-Gonzalez, Guillermoes_ES
AutorYoaly Sanchez-Lopez, Josefinaes_ES
AutorNaranjo Cruz, Alondra Yeraldies_ES
AutorPeralta-Leal, Valeriaes_ES
AutorEduardo Figuera, Luises_ES
AutorMaria Puebla-Perez, Anaes_ES
AutorAlberto Ronquillo-Carreon, Carloses_ES
AutorGraciela Puebla-Mora, Anaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas227-234es_ES
URL relacionadahttps://doi.org/10.18388/abp.2017\_2338
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen65es_ES

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