Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:39Z
Fecha de publicación2021-01-01
ResumenMexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population's treatment response.Systematic Review Registration: , identifier: CRD42020221436.es_ES
Doihttps://doi.org/10.3389/fmed.2021.665023es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5459
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Medicinees_ES
URL relacionadohttps://doi.org/10.3389/fmed.2021.665023es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Medicine
Palabra claveanti-obesity agentses_ES
Palabra claveabdominal obesity metabolic syndromees_ES
Palabra clavesystematic review and meta-analysises_ES
Palabra claverandomized clinical trialses_ES
Palabra clavetype 2 diabeteses_ES
TítuloLooking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyseses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcia-Oropesa, Esperanza M.
AutorMartinez-Lopez, Yoscelina E.
AutorRuiz-Cejudo, Sonia Maria
AutorMartinez-Ezquerro, Jose Dario
AutorDiaz-Badillo, Alvaro
AutorRamirez-Pfeiffer, Carlos
AutorBustamante-Fuentes, Alejandra
AutorLopez-Sosa, Elena B.
AutorMoctezuma-Chavez, Oscar O.
AutorNava-Gonzalez, Edna J.
AutorPerales-Torres, Adriana L.
AutorPerez-Navarro, Lucia M.
AutorRosas-Diaz, Marisol
AutorCarter, Kathleen
AutorTapia, Beatriz
AutorLopez-Alvarenga, Juan C.
AutorGarcia-Oropesa, Esperanza M.es_ES
AutorMartinez-Lopez, Yoscelina E.es_ES
AutorRuiz-Cejudo, Sonia Mariaes_ES
AutorMartinez-Ezquerro, Jose Darioes_ES
AutorDiaz-Badillo, Alvaroes_ES
AutorRamirez-Pfeiffer, Carloses_ES
AutorBustamante-Fuentes, Alejandraes_ES
AutorLopez-Sosa, Elena B.es_ES
AutorMoctezuma-Chavez, Oscar O.es_ES
AutorNava-Gonzalez, Edna J.es_ES
AutorPerales-Torres, Adriana L.es_ES
AutorPerez-Navarro, Lucia M.es_ES
AutorRosas-Diaz, Marisoles_ES
AutorCarter, Kathleenes_ES
AutorTapia, Beatrizes_ES
AutorLopez-Alvarenga, Juan C.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fmed.2021.665023
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen8es_ES

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