Src kinase signaling mediates estrous behavior induced by 5β-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:25Z
Fecha de publicación2012-01-01
ResumenThe progesterone receptor (PR) is a dual function protein that acts in the nucleus as a transcriptional factor and at the cytoplasm as a scaffold for the Src-MAPK signaling pathway. Several agents lacking affinity for the PR, such as 5 beta-reduced progestins, GnRH or prostaglandin E-2 (PGE(2)) facilitate estrous behavior in ovariectomized (ovx), estrogen-primed rats yet their action is blocked by the antiprogestin RU486. We hypothesize that these agents act by using the PR-Src-mitogen activated protein kinase alternative pathway. To test this hypothesis we used PP2, a specific inhibitor of the Src kinase family. Intraventricular infusion of 30 Kg of PP2, 30 min before behavioral testing, significantly attenuated estrous behaviors induced in estradiol benzoate (E2B)-primed rats by 5 beta-dihydroprogesterone (5 beta-DIP), 5 beta-pregnan-3 beta-ol-20-one (5 beta,3 beta-Pgl), GnRH, PGE(2) and by manual flank/vaginocervical stimulation. These results suggest that the Src signaling system, by activating mitogen-activated protein kinases, participates in the facilitation of estrous behavior in E2B-primed rats induced by agents lacking affinity for the PR. (c) 2012 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.yhbeh.2012.09.004es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5239
Idiomaenes_ES
EditorialACADEMIC PRESS INC ELSEVIER SCIENCEes_ES
RelaciónHormones and Behaviores_ES
URL relacionadohttps://doi.org/10.1016/j.yhbeh.2012.09.004es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHormones and Behavior
Palabra claveEstradioles_ES
Palabra claveLordosis behaviores_ES
Palabra claveMAPKes_ES
Palabra clavePP2es_ES
Palabra clave5 beta-Dihydroprogesteronees_ES
Palabra clave5 beta-Pregnan-3 beta-ol-20-dionees_ES
Palabra claveGnRHes_ES
Palabra clavePGE(2)es_ES
Palabra claveSrc kinasees_ES
TítuloSrc kinase signaling mediates estrous behavior induced by 5β-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLima-Hernandez, Francisco J.
AutorBeyer, Carlos
AutorGomora-Arrati, Porfirio
AutorGarcia-Juarez, Marcos
AutorEncarnacion-Sanchez, Jose L.
AutorEtgen, Anne M.
AutorGonzalez-Flores, Oscar
AutorLima-Hernandez, Francisco J.es_ES
AutorBeyer, Carloses_ES
AutorGomora-Arrati, Porfirioes_ES
AutorGarcia-Juarez, Marcoses_ES
AutorEncarnacion-Sanchez, Jose L.es_ES
AutorEtgen, Anne M.es_ES
AutorGonzalez-Flores, Oscares_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
Rango de páginas579-584es_ES
URL relacionadahttps://doi.org/10.1016/j.yhbeh.2012.09.004
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen62es_ES

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