Epigallocatechin-3-Gallate Enhances Antioxidant Activity and Improves Testicular and Epididymal Histology in Cadmium-Exposed Prepubertal Rats

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:32Z
Fecha de publicación2025-01-01
ResumenThe prepubertal period represents a critical stage of development, where the reproductive system is susceptible to toxicants such as cadmium (Cd). Cd induces oxidative stress, causes alterations in the antioxidant enzymes and testosterone concentration, and affects reproductive organs. (-)-Epigallocatechin-3-gallate (EGCG), a polyphenol with antioxidant properties, has been studied for its protective effects. We evaluated the effects of EGCG on antioxidant activity and improvement of testicular and epididymal histology in Cd-exposed prepubertal rats. Twenty-eight male Wistar rats, on postnatal day (PND) 21, were distributed into four groups: Ctrl (saline), Cd (1 mg/kg CdCl2), EGCG (10 mg/kg), and Cd+EGCG (1 mg/kg CdCl2 + 10 mg/kg EGCG). Treatments were administered intraperitoneally from PND 21 to 49. After euthanasia, blood, testes, and epididymides were collected for Cd content, testosterone concentration, antioxidant activity, and histological evaluation. Cd exposure increased blood Cd, reduced testosterone, impaired antioxidant activity, and caused epithelial disorganization in both organs. In contrast, co-administration of EGCG significantly lowered Cd accumulation, restored testosterone concentration and antioxidant enzymes, and preserved histological integrity of testes and epididymides. These findings demonstrate that EGCG exerts protective effects against Cd-induced reproductive damage during the prepubertal period, suggesting its potential therapeutic use to counteract Cd toxicity in reproductive development.es_ES
Doihttps://doi.org/10.3390/ijms26178264es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5345
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms26178264es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
Palabra claveepigallocatechin-3-gallatees_ES
Palabra clavecadmiumes_ES
Palabra clavepubertyes_ES
Palabra claveantioxidant enzymeses_ES
Palabra clavetesteses_ES
Palabra claveepididymideses_ES
TítuloEpigallocatechin-3-Gallate Enhances Antioxidant Activity and Improves Testicular and Epididymal Histology in Cadmium-Exposed Prepubertal Ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPerez-Aguirre, Sonia Guadalupe
AutorVigueras-Villasenor, Rosa Maria
AutorBonilla-Jaime, Herlinda
AutorMontes, Sergio
AutorGalvan-Arzate, Sonia
AutorHernandez-Rodriguez, Joel
Autorde Jesus, Sergio Marin
AutorCarrizales-Yanez, Leticia
AutorRojas-Castaneda, Julio Cesar
AutorArteaga-Silva, Marcela
AutorPerez-Aguirre, Sonia Guadalupees_ES
AutorVigueras-Villasenor, Rosa Mariaes_ES
AutorBonilla-Jaime, Herlindaes_ES
AutorMontes, Sergioes_ES
AutorGalvan-Arzate, Soniaes_ES
AutorHernandez-Rodriguez, Joeles_ES
Autorde Jesus, Sergio Marines_ES
AutorCarrizales-Yanez, Leticiaes_ES
AutorRojas-Castaneda, Julio Cesares_ES
AutorArteaga-Silva, Marcelaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número17es_ES
URL relacionadahttps://doi.org/10.3390/ijms26178264
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen26es_ES

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