Cadmium-Induced Neuroendocrine Alterations: Gene Expression of the Kisspeptin-GnRH Axis and Delayed Puberty in Male Rats

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:08Z
Fecha de publicación2026-01-01
ResumenPuberty is a neuroendocrine process required for sexual maturity; it is regulated by the hypothalamic-hypophysis-gonadal (HHG) axis. Kisspeptin (KISS1) plays a vital role in activating this axis by stimulating the secretion of gonadotropin-releasing hormone (GnRH). Cadmium (Cd) exposure disrupts KISS1 signaling in female rodents; its effects on hypothalamic gene expression during male puberty remain poorly understood. This study investigated the effects of Cd exposure on hypothalamic Kiss1, Kiss1r, and Gnrh1 expression, preputial separation (PS) as a marker of pubertal onset, testosterone levels, Cd concentration, and total antioxidant capacity (TAC) in the serum and hypothalamus of pubertal male Wistar rats. Animals received once a week intraperitoneal injection of CdCl2 (1 mg/Kg body weight/100 \& micro;L) or saline (100 \& micro;L) and were euthanized on postnatal day (PND) 35 or 49. Cd exposure reduced serum testosterone levels and TAC. Also, pubertal onset was delayed. At PND 35, Cd decreased hypothalamic Kiss1 expression, whereas at PND 49, it reduced Kiss1r and Gnrh1 expression. These results suggest that Cd alters hypothalamic gene expression, which may contribute to delayed puberty and impaired sexual maturity. Our findings suggest the vulnerability of puberty to exposure to Cd, acting as an endocrine disruptor and neurotoxicant, with alterations for male reproductive maturity.es_ES
Doihttps://doi.org/10.3390/toxics14030270es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4972
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónToxicses_ES
URL relacionadohttps://doi.org/10.3390/toxics14030270es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteToxics
Palabra clavepubertyes_ES
Palabra clavekisspeptines_ES
Palabra clave<italic>Kiss1</italic>es_ES
Palabra clave<italic>Kiss1r</italic>es_ES
Palabra clave<italic>Gnrh1</italic>es_ES
Palabra clavecadmiumes_ES
TítuloCadmium-Induced Neuroendocrine Alterations: Gene Expression of the Kisspeptin-GnRH Axis and Delayed Puberty in Male Ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorArteaga-Silva, Marcela
AutorCornejo de la Concha, Eduardo Miguel
AutorLandero-Huerta, Daniel Adrian
AutorMontes, Sergio
AutorRojas-Castaneda, Julio Cesar
AutorVigueras-Villasenor, Rosa Maria
AutorHernandez-Rodriguez, Joel
AutorMarin de Jesus, Sergio
AutorPerez-Aguirre, Sonia Guadalupe
AutorLopez-Ruiz, Rocio Trilce
AutorArrieta-Cruz, Isabel
AutorArteaga-Silva, Marcelaes_ES
AutorCornejo de la Concha, Eduardo Migueles_ES
AutorLandero-Huerta, Daniel Adrianes_ES
AutorMontes, Sergioes_ES
AutorRojas-Castaneda, Julio Cesares_ES
AutorVigueras-Villasenor, Rosa Mariaes_ES
AutorHernandez-Rodriguez, Joeles_ES
AutorMarin de Jesus, Sergioes_ES
AutorPerez-Aguirre, Sonia Guadalupees_ES
AutorLopez-Ruiz, Rocio Trilcees_ES
AutorArrieta-Cruz, Isabeles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
URL relacionadahttps://doi.org/10.3390/toxics14030270
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen14es_ES

Files

Collections

Documentación Cientifica