Adipocytokines in Steatotic Liver Surgery/Transplantation

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:56Z
Fecha de publicación2018-01-17
ResumenBecause of the shortage of liver grafts available for transplantation, the restrictions on graft quality have been relaxed, and marginal grafts, such as steatotic livers, are now accepted. However, this policy change has not solved the problem, because steatotic liver grafts tolerate ischemia-reperfusion (I/R) injury poorly. Adipocytokines differentially modulate steatosis, inflammation, and fibrosis and are broadly present in hepatic resections and transplants. The potential use of adipocytokines as biomarkers of the severity of steatosis and liver damage to aid the identification of high-risk steatotic liver donors and to evaluate hepatic injury in the postoperative period are discussed. The hope of finding new therapeutic strategies aimed specifically at protecting steatotic livers undergoing surgery is a strong impetus for identifying the mechanisms responsible for hepatic failure after major surgical intervention. Hence, the most recently described roles of adipocytokines in steatotic livers subject to I/R injury are discussed, the conflicting results in the literature are summarized, and reasons are offered as to why strategic pharmacologic control of adipocytokines has yet to yield clinical benefits. After this, the next steps needed to transfer basic knowledge about adipocytokines into clinical practice to protect marginal livers subject to I/R injury are presented. Recent strategies based on adipocytokine regulation, which have shown efficacy in various pathologies, and hold promise for hepatic resection and transplantation are also outlined.es_ES
Doihttps://doi.org/10.1097/tp.0000000000002098es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2650
Idiomaenes_ES
EditorialWolters Kluweres_ES
RelaciónTransplantationes_ES
URL relacionadohttps://doi.org/10.1097/tp.0000000000002098es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteTransplantation
Palabra claveAdipokinees_ES
Palabra claveMedicinees_ES
Palabra claveSteatosises_ES
Palabra claveLiver transplantationes_ES
Palabra claveReperfusion injuryes_ES
Palabra claveFatty liveres_ES
Palabra claveTransplantationes_ES
Palabra claveIntensive care medicinees_ES
Palabra claveIschemiaes_ES
Palabra claveSurgeryes_ES
Palabra claveInternal medicinees_ES
Palabra claveLeptines_ES
ClasificaciónLiver Disease Diagnosis and Treatmentes_ES
TítuloAdipocytokines in Steatotic Liver Surgery/Transplantationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorJiménez‐Castro, Mónica B.
AutorCasillas-Ramírez, Araní
AutorNegrete-Sánchez, Elsa
AutorLeón, Cindy G. Avalos-de
AutorGracia‐Sancho, Jordi
AutorPeralta, Carmen
AutorJiménez‐Castro, Mónica B.es_ES
AutorCasillas-Ramírez, Araníes_ES
AutorNegrete-Sánchez, Elsaes_ES
AutorLeón, Cindy G. Avalos-dees_ES
AutorGracia‐Sancho, Jordies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas71-77es_ES
URL relacionadahttps://doi.org/10.1097/tp.0000000000002098
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen103es_ES

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