Melanin-concentrating hormone receptor 1 antagonists

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:37Z
Fecha de publicación2008-01-01
ResumenObesity is a chronic disease characterized by the accumulation of excess adipose tissue associated with an increased risk of multiple morbidities and mortality. At the present time, only three drugs have been approved by the Food and Drug Administration (FDA) for the treatment of obesity. Agonists and antagonists of some of the substances implicated in the regulation of energy homeostasis represent opportunities for anti-obesity drug development. The most promising targets are alpha-melanocyte stimulating hormone (alpha-MSH) receptors, cannabinoid receptors, the 5-hydroxytryptamine (5-HT) receptors and melanin-concentrating hormone (MCH) receptors. MCH receptors could be major potential targets for the treatment of obesity. Many pharmaceutical companies have described MCH-R1 antagonists that have appeared over the past year. Recently, two compounds went into phase I clinical trials that evaluate MCH receptor antagonists as a new perspective for the pharmacologic treatment of obesity. In this review, structure-activity relationships (SAR) in the development of MCH-R1 antagonists are provided.es_ES
Doihttps://doi.org/10.2174/092986708784049621es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4439
Idiomaenes_ES
EditorialBENTHAM SCIENCE PUBL LTDes_ES
RelaciónCurrent Medicinal Chemistryes_ES
URL relacionadohttps://doi.org/10.2174/092986708784049621es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteCurrent Medicinal Chemistry
Palabra claveantagonistses_ES
Palabra clavemelanin-concentrating hormone (MCH)es_ES
Palabra clavemelanin-concentrating hormone receptor 1 (MCH-R1)es_ES
Palabra clavestructure-activity relationship (SAR)es_ES
Palabra claveobesityes_ES
TítuloMelanin-concentrating hormone receptor 1 antagonistses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRivera, Gildardo
AutorBocanegra-Garcia, Virgilio
AutorGaliano, Silvia
AutorCirauqui, Nuria
AutorCeras, Javier
AutorPerez, Silvia
AutorAldana, Ignacio
AutorMonge, Antonio
AutorRivera, Gildardoes_ES
AutorBocanegra-Garcia, Virgilioes_ES
AutorGaliano, Silviaes_ES
AutorCirauqui, Nuriaes_ES
AutorCeras, Javieres_ES
AutorPerez, Silviaes_ES
AutorAldana, Ignacioes_ES
AutorMonge, Antonioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número10es_ES
Rango de páginas1025-1043es_ES
URL relacionadahttps://doi.org/10.2174/092986708784049621
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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