Inhibitory effect of chronic oral treatment with fluoxetine on capsaicin-induced external carotid vasodilatation in anaesthetised dogs

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:22Z
Fecha de publicación2015-01-01
ResumenBackground During migraine, capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nociception. Moreover, 5-HT is involved in the pathophysiology of migraine and depression. Interestingly, some limited lines of evidence suggest that fluoxetine may be effective in migraine prophylaxis, but the underlying mechanisms are uncertain. Hence, this study investigated the canine external carotid vasodilator responses to capsaicin, α-CGRP and acetylcholine before and after acute and chronic oral treatment with fluoxetine. Methods Forty-eight vagosympathectomised male mongrel dogs were prepared to measure blood pressure, heart rate and external carotid blood flow. The thyroid artery was cannulated for infusions of agonists. In 16 of these dogs, a spinal cannula was inserted (C<sub>1</sub>-C<sub>3</sub>) for infusions of 5-HT. Results The external carotid vasodilator responses to capsaicin, α-CGRP and acetylcholine remained unaffected after intracarotid or i.v. fluoxetine. In contrast, the vasodilator responses to capsaicin, but not those to α-CGRP or acetylcholine, were inhibited after chronic oral treatment with fluoxetine (300 μg/kg; for 90 days) or intrathecal 5-HT. Conclusions Chronic oral fluoxetine inhibited capsaicin-induced external carotid vasodilatation, and this inhibition could partly explain its potential prophylactic antimigraine action.es_ES
Doihttps://doi.org/10.1177/0333102414566818es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6138
Idiomaenes_ES
EditorialSAGE Publications Ltdes_ES
RelaciónCephalalgiaes_ES
URL relacionadohttps://doi.org/10.1177/0333102414566818es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteCephalalgia
Palabra clave5-HTes_ES
Palabra claveCapsaicines_ES
Palabra clavefluoxetinees_ES
Palabra clavemigrainees_ES
Palabra clavevasodilatationes_ES
Palabra claveα-CGRPes_ES
TítuloInhibitory effect of chronic oral treatment with fluoxetine on capsaicin-induced external carotid vasodilatation in anaesthetised dogses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMuñoz-Islas, Enriqueta
AutorGonzález-Hernández, Abimael
AutorLozano-Cuenca, Jair
AutorRamírez-Rosas, Martha Beatríz
AutorMedina-Santillán, Roberto
AutorCenturión, David
AutorMaassenvandenbrink, Antoinette
AutorVillalón, Carlos M.
AutorMuñoz-Islas, Enriquetaes_ES
AutorGonzález-Hernández, Abimaeles_ES
AutorLozano-Cuenca, Jaires_ES
AutorRamírez-Rosas, Martha Beatrízes_ES
AutorMedina-Santillán, Robertoes_ES
AutorCenturión, Davides_ES
AutorMaassenvandenbrink, Antoinettees_ES
AutorVillalón, Carlos M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número12es_ES
Rango de páginas1041-1053es_ES
URL relacionadahttps://doi.org/10.1177/0333102414566818
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen35es_ES

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