Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:33Z
Fecha de publicación2013-01-01
ResumenThe present study tested the hypothesis that the Janus kinase 2, Src tyrosine kinases, and mitogen-activated protein kinase interact to regulate lordosis behavior induced by leptin in ovariectomized, estrogen-primed rats. The role of protein kinase A and protein kinase C in lordosis facilitation by leptin was also assessed. In experiment 1, the intracerebroventricular administration of leptin to ovariectomized, estradiol-primed rats significantly stimulated lordosis behavior at 1, 2 and 4 h post-injection tests. In experiment 2, the Janus kinase 2 inhibitor AG490, the Src tyrosine kinase inhibitor PP2 and the mitogen-activated protein kinase inhibitor PD98059 were administered into the right lateral ventricle before leptin. The lordosis quotient and the lordosis score induced by leptin were significantly decreased by each of these kinase inhibitors. In experiment 3, we examined the effects of RpcAMPS and bisindolylmaleimide, protein kinase A and protein kinase C inhibitors on the lordosis elicited by leptin administration. Lordosis behavior induced by leptin was significantly decreased by both the protein kinase A and protein kinase C inhibitors at 1 h post-leptin injection. The results confirm that multiple intracellular pathways participate in the expression of lordosis behavior in estrogen-primed rats elicited by leptin. (C) 2013 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.pbb.2013.05.014es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5368
Idiomaenes_ES
EditorialPERGAMON-ELSEVIER SCIENCE LTDes_ES
RelaciónPharmacology Biochemistry and Behaviores_ES
URL relacionadohttps://doi.org/10.1016/j.pbb.2013.05.014es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuentePharmacology Biochemistry and Behavior
Palabra claveLordosis behaviores_ES
Palabra claveLeptines_ES
Palabra claveMAPKes_ES
Palabra clavePKAes_ES
Palabra clavePKCes_ES
Palabra claveSrces_ES
TítuloLordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathwayses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcia-Juarez, Marcos
AutorBeyer, Carlos
AutorGomora-Arrati, Porfirio
AutorDominguez-Ordonez, Raymundo
AutorLima-Hernandez, Francisco J.
AutorEguibar, Jose R.
AutorGalicia-Aguas, Yadira L.
AutorEtgen, Anne M.
AutorGonzalez-Flores, Oscar
AutorGarcia-Juarez, Marcoses_ES
AutorBeyer, Carloses_ES
AutorGomora-Arrati, Porfirioes_ES
AutorDominguez-Ordonez, Raymundoes_ES
AutorLima-Hernandez, Francisco J.es_ES
AutorEguibar, Jose R.es_ES
AutorGalicia-Aguas, Yadira L.es_ES
AutorEtgen, Anne M.es_ES
AutorGonzalez-Flores, Oscares_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas13-18es_ES
URL relacionadahttps://doi.org/10.1016/j.pbb.2013.05.014
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen110es_ES

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