Prevalence of inhibitors and clinical characteristics in patients with haemophilia in a middle‐income Latin American country

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:12Z
Fecha de publicación2020-03-01
ResumenINTRODUCTION: Development of inhibitors is the most serious complication in patients with haemophilia (PWH). The prevalence of inhibitors in patients with severe haemophilia A (HA) is approximately 25%-30%. Inhibitor prevalence differs among populations. Some studies report a prevalence of almost twice in Hispanic as compared to Caucasian patients. Most data available, on the prevalence of inhibitors and their predisposing factors, originate from centres in developed countries. AIM: Establish the prevalence of inhibitors of FVIII and FIX in Mexico. METHODS: This was an observational, cross-sectional and descriptive study. The records of all patients diagnosed with haemophilia A (HA) or B (HB), with and without inhibitors, were included. Clinical and demographical characteristics of patients with inhibitors were assessed. Statistical analysis was performed using IBM SPSS version 22. The Ethics Committees of the various participating institutions approved this study. RESULTS: A total of 1455 patients from the 20 participating centres were recruited, from which 1208 (83.02%) had HA and 247 (16.97%) were diagnosed with HB. The presence of inhibitors in severe HA was reported in 93/777(11.96%), and 10/162 (6.17%) in severe HB. Of them, 91.7% exhibited high titres in HA and 100% in HB. CONCLUSION: In Mexico, the general prevalence of inhibitors varies considerably among centres. This study established a basis of comparison for future development and advances in the treatment and follow-up of patients. These findings also augment our understanding of risk factors related to inhibitor development.es_ES
Doihttps://doi.org/10.1111/hae.13951es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2866
Idiomaenes_ES
EditorialWileyes_ES
RelaciónHaemophiliaes_ES
URL relacionadohttps://doi.org/10.1111/hae.13951es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHaemophilia
Palabra claveMedicinees_ES
Palabra claveHaemophiliaes_ES
Palabra claveObservational studyes_ES
Palabra claveHaemophilia Aes_ES
Palabra claveHaemophilia Bes_ES
Palabra claveInternal medicinees_ES
Palabra clavePediatricses_ES
Palabra claveClinical triales_ES
Palabra claveComplicationes_ES
Palabra claveFamily medicinees_ES
ClasificaciónHemophilia Treatment and Researches_ES
TítuloPrevalence of inhibitors and clinical characteristics in patients with haemophilia in a middle‐income Latin American countryes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorVillarreal‐Martínez, Laura
AutorGarcı́a-Chávez, Jaime
AutorSánchez‐Jara, Berenice
AutorMoreno‐González, Aida Mashenka
AutorSoto‐Padilla, Janet
AutorAquino‐Fernández, Efraín
AutorParedes‐Aguilera, Rogelio
AutorMaldonado‐Silva, Karla
AutorRodríguez‐Castillejos, Cecilia
AutorGonzález‐Ávila, Ana Itamar
AutorMora‐Torres, María
AutorTiznado-García, Héctor Manuel
AutorPadilla‐Durón, Natalia Elizabeth
AutorLuna‐Silva, Nuria Citlali
AutorGutiérrez-Juárez, Erick Israel
AutorNemi‐Cueto, Jorge
AutorGómez‐González, Claudia Sofía
AutorLeón‐Figueroa, Ricardo De
AutorLópez‐Miranda, Adela
AutorRíos‐Osuna, Mirna Guadalupe
AutorTamez-Gómez, Edna Liliana
AutorReyes‐Espinoza, Elio Aarón
AutorDomínguez‐Varela, Irving Armando
AutorGonzález‐Martínez, Gerardo
AutorGodoy‐Salinas, Elias Adán
AutorVillarreal‐Martínez, Lauraes_ES
AutorGarcı́a-Chávez, Jaimees_ES
AutorSánchez‐Jara, Berenicees_ES
AutorMoreno‐González, Aida Mashenkaes_ES
AutorSoto‐Padilla, Janetes_ES
AutorAquino‐Fernández, Efraínes_ES
AutorParedes‐Aguilera, Rogelioes_ES
AutorMaldonado‐Silva, Karlaes_ES
AutorRodríguez‐Castillejos, Ceciliaes_ES
AutorGonzález‐Ávila, Ana Itamares_ES
AutorMora‐Torres, Maríaes_ES
AutorTiznado-García, Héctor Manueles_ES
AutorPadilla‐Durón, Natalia Elizabethes_ES
AutorLuna‐Silva, Nuria Citlalies_ES
AutorGutiérrez-Juárez, Erick Israeles_ES
AutorNemi‐Cueto, Jorgees_ES
AutorGómez‐González, Claudia Sofíaes_ES
AutorLeón‐Figueroa, Ricardo Dees_ES
AutorLópez‐Miranda, Adelaes_ES
AutorRíos‐Osuna, Mirna Guadalupees_ES
AutorTamez-Gómez, Edna Lilianaes_ES
AutorReyes‐Espinoza, Elio Aarónes_ES
AutorDomínguez‐Varela, Irving Armandoes_ES
AutorGonzález‐Martínez, Gerardoes_ES
AutorGodoy‐Salinas, Elias Adánes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas290-297es_ES
URL relacionadahttps://doi.org/10.1111/hae.13951
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen26es_ES

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