Prenatal Co-Exposure to Manganese, Mercury, and Lead, and Neurodevelopment in Children during the First Year of Life

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:19Z
Fecha de publicación2022-01-01
ResumenLead (Pb), mercury (Hg), and manganese (Mn) are neurotoxic, but little is known about the neurodevelopmental effects associated with simultaneous prenatal exposure to these metals. We aimed to study the associations of Pb, Hg, and Mn prenatal levels (jointly and separately) with neurodevelopment in the first year of life. Methods: Pb, Hg, and Mn blood lead levels were measured in 253 pregnant women. Their offspring's neurodevelopment was assessed through the Bayley Scale of Infant Development III (R) at one, three, six, and twelve months. The metals' mean blood levels (mu g/L) were Pb = 11.2, Hg = 2.1, and Mn = 10.2. Mean language, cognitive, and motor development scores of the infants at each age were between low-average and average. Multilevel models' results showed that language development coefficients of the offspring decreased by 1.5 points per 1 mu g/dL increase in maternal blood lead levels (p = 0.002); the magnitude of the aforementioned association increased in children with maternal blood Mn < 9.6 mu g/L (beta = -1.9, p = 0.003) or Hg > 1.9 mu g/L (beta = -1.6, p = 0.013). Cognitive and motor development had negative associations with maternal blood Pb levels; the latter was statistically significant when the interaction term between Pb, Mn, and Hg was included (beta = -0.037, p = 0.03). Prenatal exposure to low Pb levels may impair infants' neurodevelopment in the first year of life, even more so if they are exposed to Hg or deficient in Mn.es_ES
Doihttps://doi.org/10.3390/ijerph192013020es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5152
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Environmental Research and Public Healthes_ES
URL relacionadohttps://doi.org/10.3390/ijerph192013020es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Environmental Research and Public Health
Palabra claveleades_ES
Palabra clavemanganesees_ES
Palabra clavemercuryes_ES
Palabra claveco-exposurees_ES
Palabra claveprenatales_ES
Palabra clavechildrenes_ES
Palabra claveneurodevelopmentes_ES
TítuloPrenatal Co-Exposure to Manganese, Mercury, and Lead, and Neurodevelopment in Children during the First Year of Lifees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorFarias, Paulina
AutorHernandez-Bonilla, David
AutorMoreno-Macias, Hortensia
AutorMontes-Lopez, Sergio
AutorSchnaas, Lourdes
AutorLuis Texcalac-Sangrador, Jose
AutorRios, Camilo
AutorRiojas-Rodriguez, Horacio
AutorFarias, Paulinaes_ES
AutorHernandez-Bonilla, Davides_ES
AutorMoreno-Macias, Hortensiaes_ES
AutorMontes-Lopez, Sergioes_ES
AutorSchnaas, Lourdeses_ES
AutorLuis Texcalac-Sangrador, Josees_ES
AutorRios, Camiloes_ES
AutorRiojas-Rodriguez, Horacioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número20es_ES
URL relacionadahttps://doi.org/10.3390/ijerph192013020
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen19es_ES

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