Advances in the Development of Carbonic Anhydrase Inhibitors as New Antiprotozoal Agents

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:40Z
Fecha de publicación2024-01-01
ResumenBackground: Parasitic diseases are a public health problem despite the existence of drugs for their treatment. These treatments have variable efficacy and, in some cases, serious adverse effects. There has been interest in the enzyme carbonic anhydrase (CA) in the last two decades since it is essential in the life cycle of various parasites due to its important participation in processes such as pyrimidine synthesis, HCO3 - transport across cell membranes, and the maintenance of intracellular pH and ion transport (Na+, K+, and H+), among others. Objective: In this review, CA was analyzed as a pharmacological target in etiological agents of malaria, American trypanosomiasis, leishmaniasis, amoebiasis, and trichomoniasis. The CA inhibitors´ design, binding mode, and structure-activity relationship are also discussed. Conclusion: According to this review, advances in discovering compounds with potent inhibitory activity suggest that CA is a candidate for developing new antiprotozoal agents.es_ES
Doihttps://doi.org/10.2174/0109298673249553231018070920es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1650
Idiomaeses_ES
EditorialBentham Science Publishers Ltd.es_ES
RelaciónCurrent Medicinal Chemistryes_ES
URL relacionadohttps://doi.org/10.2174/0109298673249553231018070920es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCurrent Medicinal Chemistry
TítuloAdvances in the Development of Carbonic Anhydrase Inhibitors as New Antiprotozoal Agentses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorOrtiz-Perez, Eyra
AutorVazquez-Jimenez, Lenci K.
AutorPaz-Gonzalez, Alma D.
AutorDelgado-Maldonado, Timoteo
AutorGonzález-González, Alonzo
AutorGaona-Lopez, Carlos
AutorMoreno-Herrera, Antonio
AutorVazquez, Karina
AutorRivera, Gildardo
AutorOrtiz-Perez, Eyraes_ES
AutorVazquez-Jimenez, Lenci K.es_ES
AutorPaz-Gonzalez, Alma D.es_ES
AutorDelgado-Maldonado, Timoteoes_ES
AutorGonzález-González, Alonzoes_ES
AutorGaona-Lopez, Carloses_ES
AutorMoreno-Herrera, Antonioes_ES
AutorVazquez, Karinaes_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número41es_ES
Rango de páginas6735-6759es_ES
URL relacionadahttps://doi.org/10.2174/0109298673249553231018070920
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen31es_ES

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