Regulation of Adiponectin and Resistin in Liver Transplantation Protects Grafts from Extended-Criteria Donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:18Z
Fecha de publicación2025-01-01
ResumenThe donor shortage increases liver transplantation (LT) waiting lists, making it crucial to consider extendedcriteria donors, such as steatotic donors after brain death (DBDs) or cardiocirculatory death (DCDs). Nevertheless, steatosis, brain death, and cardiocirculatory death are key risk factors for poor LT outcomes. Herein, the role and therapeutic usefulness of several adipocytokines was investigated to protect such grafts from extended-criteria donors. Sprague rats with nutritionally induced steatosis were used in an experimental LT model with grafts from DBDs or DCDs. Adiponectin, resistin, and visfatin were measured and pharmacologically modulated, and effects on liver injury were assessed. Visfatin played no role under conditions of either DBD or DCD LT. Brain death increased adiponectin and reduced resistin. Adiponectin harmed steatotic and nonsteatotic DBD grafts, via a resistin-dependent mechanism; restraining adiponectin increased resistin, reducing damage. Resistin treatment protected both types of DBD grafts, whereas suppressing it increased damage. This adiponectin-resistin pathway was dependent on protein kinase C. In DCD LT, adiponectin and resistin were not modified in nonsteatotic grafts, but reduced in steatotic ones. Adiponectin or resistin treatments protected steatotic grafts: hepatic adiponectin activated AMP-activated of both adipocytokines increased both signaling pathways, intensifying protection. These data suggest that pharmacologic modulation of adiponectin and resistin as therapies might potentially be translated to clinical studies to improve surgical outcomes for LT from extended-criteria donors. (Am J Pathol 2025, 195:es_ES
Doihttps://doi.org/10.1016/j.ajpath.2024.10.016es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5106
Idiomaenes_ES
EditorialELSEVIER SCIENCE INCes_ES
RelaciónAmerican Journal of Pathologyes_ES
URL relacionadohttps://doi.org/10.1016/j.ajpath.2024.10.016es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteAmerican Journal of Pathology
TítuloRegulation of Adiponectin and Resistin in Liver Transplantation Protects Grafts from Extended-Criteria Donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCasillas-Ramirez, Arani
AutorMaroto-Serrat, Cristina
AutorSanus, Francisco
AutorMico-Carnero, Marc
AutorRojano-Alfonso, Carlos
AutorCabrer, Margalida
AutorPeralta, Carmen
AutorCasillas-Ramirez, Aranies_ES
AutorMaroto-Serrat, Cristinaes_ES
AutorSanus, Franciscoes_ES
AutorMico-Carnero, Marces_ES
AutorRojano-Alfonso, Carloses_ES
AutorCabrer, Margalidaes_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas494-527es_ES
URL relacionadahttps://doi.org/10.1016/j.ajpath.2024.10.016
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen195es_ES

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