Molecular Assessment, Drug-Resistant Profile, and Spacer Oligonucleotide Typing (Spoligotyping) of Mycobacterium tuberculosis Strains From Tamaulipas, Mexico

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:18Z
Fecha de publicación2014-01-01
ResumenBackground Tuberculosis remains a serious global health problem involving one-third of the world population. A wide diversity of Mycobacterium tuberculosis strains cause about 1.5 million deaths/year worldwide, but in developing countries, the genetic diversity of M. tuberculosis strains remains largely unknown. We conducted a first insight into the population diversity of M. tuberculosis strains from Tamaulipas, Mexico. Methods Seventy-two M. tuberculosis strains were identified and genetic diversity determined by spoligotyping. Drug sensibility testing and punctual mutations in inhA, ahpC, rpoB, and katG genes were assessed. Results Spoligotyping analysis showed a higher prevalence of LAM9 > T1 > Haarlem3 subfamilies among 53 spoligotype patterns. Unexpectedly, five Beijing strains conforming four unique spoligopatterns were recovered. The more frequently isolated strains (LAM9 and T1), but none of the Beijing strains, were found resistant to INH or RIF. Also, no drug resistance was found among Haarlem3 isolates. The katG(315) gene mutation was found in 83\% of INH-resistant strains, whereas rpoB(526) were associated in only 43\% of RIF M. tuberculosis drug-resistant strains. Conclusions This and other studies report a high rate of orphan spoligotypes, which highlights the need for genotyping implementation as a routine technique for better understanding of M. tuberculosis strains in developing countries such as Mexico.es_ES
Doihttps://doi.org/10.1002/jcla.21650es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5125
Idiomaenes_ES
EditorialJOHN WILEY \& SONS INCes_ES
RelaciónJournal of Clinical Laboratory Analysises_ES
URL relacionadohttps://doi.org/10.1002/jcla.21650es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Clinical Laboratory Analysis
Palabra claveBeijinges_ES
Palabra clavekatGes_ES
Palabra clavetuberculosises_ES
Palabra clavespoligotypinges_ES
Palabra claverpoBes_ES
TítuloMolecular Assessment, Drug-Resistant Profile, and Spacer Oligonucleotide Typing (Spoligotyping) of Mycobacterium tuberculosis Strains From Tamaulipas, Mexicoes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorBocanegra-Garcia, Virgilio
AutorGarza-Gonzalez, Elvira
AutorLizeth Cruz-Pulido, Wendy
AutorLizeth Guevara-Molina, Yahaira
AutorCantu-Ramirez, Ruben
AutorGonzalez, Gloria M.
AutorRivera, Gildardo
AutorPalma-Nicolas, Jose P.
AutorBocanegra-Garcia, Virgilioes_ES
AutorGarza-Gonzalez, Elviraes_ES
AutorLizeth Cruz-Pulido, Wendyes_ES
AutorLizeth Guevara-Molina, Yahairaes_ES
AutorCantu-Ramirez, Rubenes_ES
AutorGonzalez, Gloria M.es_ES
AutorRivera, Gildardoes_ES
AutorPalma-Nicolas, Jose P.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas97-103es_ES
URL relacionadahttps://doi.org/10.1002/jcla.21650
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen28es_ES

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