Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-10-05T16:33:37Z | |
| Fecha de publicación | 2021-01-01 | |
| Resumen | Microbiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The bidirectional relationship between the gut, its microbiota and the liver is referred to as the gut-liver axis. The translocation of bacterial products from the intestine to the liver induces inflammation in different cell types such as Kupffer cells, and a fibrotic response in hepatic stellate cells, resulting in deleterious effects on hepatocytes. Moreover, ischemia-reperfusion injury, a consequence of liver surgery, alters the microbiota profile, affecting inflammation, the immune response and even liver regeneration. Microbiota also seems to play an important role in post-operative outcomes (i.e., liver transplantation or liver resection). Nonetheless, studies to determine changes in the gut microbial populations produced during and after surgery, and affecting liver function and regeneration are scarce. In the present review we analyze and discuss the preclinical and clinical studies reported in the literature focused on the evaluation of alterations in microbiota and its products as well as their effects on post-operative outcomes in hepatic surgery. | es_ES |
| Doi | https://doi.org/10.3390/ijms22010044 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/5420 | |
| Idioma | en | es_ES |
| Editorial | MDPI | es_ES |
| Relación | International Journal of Molecular Sciences | es_ES |
| URL relacionado | https://doi.org/10.3390/ijms22010044 | es_ES |
| Derechos | Acceso abierto (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_abf2 | es_ES |
| Fuente | International Journal of Molecular Sciences | |
| Palabra clave | microbiota | es_ES |
| Palabra clave | liver transplantation | es_ES |
| Palabra clave | partial hepatectomy | es_ES |
| Palabra clave | liver surgery | es_ES |
| Palabra clave | ischemia-reperfusion | es_ES |
| Título | Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | Mico-Carnero, Marc | |
| Autor | Rojano-Alfonso, Carlos | |
| Autor | alvarez-Mercado, Ana Isabel | |
| Autor | Gracia-Sancho, Jordi | |
| Autor | Casillas-Ramirez, Arani | |
| Autor | Peralta, Carmen | |
| Autor | Mico-Carnero, Marc | es_ES |
| Autor | Rojano-Alfonso, Carlos | es_ES |
| Autor | alvarez-Mercado, Ana Isabel | es_ES |
| Autor | Gracia-Sancho, Jordi | es_ES |
| Autor | Casillas-Ramirez, Arani | es_ES |
| Autor | Peralta, Carmen | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Número | 1 | es_ES |
| URL relacionada | https://doi.org/10.3390/ijms22010044 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 22 | es_ES |