Conservation and immunogenicity of the mosquito ortholog of the tick-protective antigen, subolesin

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2009-01-01
ResumenThe control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. The ortholog of the tick-protective antigen, subolesin, was identified in Aedes albopictus and found to have conserved epitopes in ticks and mosquitoes. RNA interference with the tick and mosquito double-stranded RNA in three tick species resulted in significant gene knockdown and decreased tick weight and/or survival. Feeding Anopheles atroparvus, Aedes caspius, and Culex pipiens female mosquitoes on an A. albopictus subolesin hyperimmune serum resulted in 11 +/- 5\% to 29 +/- 6\% survival inhibition when compared to controls fed on preimmune serum. Feeding sand flies, Phlebotomus perniciosus, on antimosquito subolesin ortholog protein antibodies inhibited female survival and the number of larvae and adults obtained after hatching by 28 +/- 22\% and 16 +/- 3\%, respectively, when compared to controls. Vaccination with tick and mosquito subolesin ortholog proteins significantly reduced Ixodes scapularis tick infestation and weight in a similar way. However, vaccination with the recombinant mosquito subolesin ortholog antigen did not protect against Amblyomma americanum and Rhipicephalus sanguineus tick infestations. Collectively, these preliminary results provided the first evidence that development of vaccines may be possible for control of multiple arthropod vectors using subolesin orthologs but suggested that multiple antigens may be required to produce an effective vaccine.es_ES
Doihttps://doi.org/10.1007/s00436-009-1368-2es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5436
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónParasitology Researches_ES
URL relacionadohttps://doi.org/10.1007/s00436-009-1368-2es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteParasitology Research
TítuloConservation and immunogenicity of the mosquito ortholog of the tick-protective antigen, subolesines_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCanales, Mario
AutorNaranjo, Victoria
AutorAlmazan, Consuelo
AutorMolina, Ricardo
AutorTsuruta, Suzana A.
AutorSzabo, Matias P. J.
AutorManzano-Roman, Raul
AutorPerez de la Lastra, Jose M.
AutorKocan, Katherine M.
AutorIsabel Jimenez, Maria
AutorLucientes, Javier
AutorVillar, Margarita
Autorde la Fuente, Jose
AutorCanales, Marioes_ES
AutorNaranjo, Victoriaes_ES
AutorAlmazan, Consueloes_ES
AutorMolina, Ricardoes_ES
AutorTsuruta, Suzana A.es_ES
AutorSzabo, Matias P. J.es_ES
AutorManzano-Roman, Raules_ES
AutorPerez de la Lastra, Jose M.es_ES
AutorKocan, Katherine M.es_ES
AutorIsabel Jimenez, Mariaes_ES
AutorLucientes, Javieres_ES
AutorVillar, Margaritaes_ES
Autorde la Fuente, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas97-111es_ES
URL relacionadahttps://doi.org/10.1007/s00436-009-1368-2
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen105es_ES

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