Treatment with progesterone prevented the motor impairment induced by poisoning with seeds of cicada (Dioon spinulosum) in the male rat

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:28Z
Fecha de publicación2009-01-01
ResumenThe chronic consumption of cycad seeds has been associated with neurodegenerative diseases, which are predominant in masculine gender. In Mexico, the cycad seeds (Dioon spinulosum) ared used as a maize substitute and at experimental level produce a motor deficit; probably caused by its neurotoxic compounds. Progesterone could prevent the neurotoxic effects against traumatic brain injury, hypoxia and neuronal death induced by colchicine in the CNS. In addition, progesterone could prevent these neurotoxic effects produced by the chronic administration of cycad seeds (Dioon spinulosum) in rats, a possibility explored in the present study. Male wistar rats were randomly divided in 4 groups: a) a control group received 1 ml purified water (PO) and oil (0.2 ml, s.c.); b) a cycad group received a cycad seed 5g/kg (PO) and oil (0.2 ml, s.c.); c) another group received 1 ml of purified water (PO) and progesterone (3mg/kg, s.c.) and d) the last group received cycad seed and progesterone. All treatments were administered daily during 40 days and the effect was evaluated in behavioral tests (open filed and forced swim) were conducted on 20, 30 and 40 days of treatment. The cycad group decreased the number of squares crossed in the open field whereas, in the forced swim test, rotational behavior was only observed in the group administered with cycad seeds, this effect was prevented by previous progesterone treatment. The vehicle and progesterone administration did not produce the rotational behavior per se. In conclusion, progesterone prevents the motor deficit induced by the chronic consumption of cycad seeds in forced swim rats.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6231
Idiomaeses_ES
RelaciónRevista de Toxicologiaes_ES
URL relacionadohttps://www.scopus.com/pages/publications/78149490821?origin=resultslistes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteRevista de Toxicologia
Palabra claveCycades_ES
Palabra claveDioon spinulosumes_ES
Palabra claveNeutoroxices_ES
Palabra claveProgesteronees_ES
Palabra claveRotational behaviores_ES
TítuloTreatment with progesterone prevented the motor impairment induced by poisoning with seeds of cicada (Dioon spinulosum) in the male rates_ES
Título alternativoEl tratamiento con progesterona previene las alteraciones motoras inducidas por la intoxicación con semillas de cícada (Dioon spinulosum) en la rata machoes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRivadeneyra-Domínguez, E.
AutorSaavedra, M.
AutorRodríguez-Landa, J.F.
AutorRivadeneyra-Domínguez, E.es_ES
AutorSaavedra, M.es_ES
AutorRodríguez-Landa, J.F.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2-3es_ES
Rango de páginas117-121es_ES
URL relacionadahttps://www.scopus.com/pages/publications/78149490821?origin=resultslist
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen26es_ES

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