Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2007-01-01
ResumenThe coevolution of ticks and the pathogens that they transmit has ensured their Mutual survival. In these studies, we used a functional genomics approach to characterize tick genes regulated in response to Anaplasma marginale, infection. Differentially regulated genes/proteins were identified by suppression-subtractive hybridization and differential in-gel electrophoresis analyses of cultured IDES tick cells infected with A. 121(marginale. Nine of 17 of these genes were confirmed by real-time RT-PCR to be differentially regulated in ticks and/or IDES tick cells in response to A marginale infection. RNA interference was used for functional studies. Six genes, which encode putative selenoprotein W2a, hematopoietic stem/progenitor cells protein-like, proteasome 26S Subunit, ferritin, GST, and subolesin control, were found to affect A. marginale infection in IDES tick cells. Four genes, which encode putative GST, salivary selenoprotein M, vATPase, and ubiquitin, affected A. marginale infection in different sites of development in ticks. The results of these studies demonstrated that a molecular mechanism occurs by which tick cell gene expression mediates the A. marginale developmental cycle and trafficking through ticks. (c) 2007 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.ygeno.2007.08.009es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5451
Idiomaenes_ES
EditorialACADEMIC PRESS INC ELSEVIER SCIENCEes_ES
RelaciónGenomicses_ES
URL relacionadohttps://doi.org/10.1016/j.ygeno.2007.08.009es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteGenomics
Palabra clavetickes_ES
Palabra claveAnaplasma marginalees_ES
Palabra claveRNA interferencees_ES
Palabra claveIDE8 cellses_ES
TítuloFunctional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginalees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autorde la Fuente, Jose
AutorBlouin, Edmour F.
AutorManzano-Roman, Raul
AutorNaranjo, Victoria
AutorAlmazan, Consuelo
AutorManuel Perez de la Lastra, Jose
AutorZlvkovic, Zorica
AutorJongejan, Frans
AutorKocan, Katherine M.
Autorde la Fuente, Josees_ES
AutorBlouin, Edmour F.es_ES
AutorManzano-Roman, Raules_ES
AutorNaranjo, Victoriaes_ES
AutorAlmazan, Consueloes_ES
AutorManuel Perez de la Lastra, Josees_ES
AutorZlvkovic, Zoricaes_ES
AutorJongejan, Franses_ES
AutorKocan, Katherine M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número6es_ES
Rango de páginas712-722es_ES
URL relacionadahttps://doi.org/10.1016/j.ygeno.2007.08.009
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen90es_ES

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