Ovarian toxicity of environmental contaminants: 50 shades of grey

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:18Z
Fecha de publicación2016-01-01
ResumenExposure to environmental contaminants is thought to be important in the development of adverse effects on reproductive health. While the adverse effects of environmental contaminants on semen quality and testicular function have been well studied, effects on ovarian function are less well defined. Epidemiological studies have linked exposure to environmental contaminants with adverse effects on menstrual cycle characteristics, infertility, and earlier age of menopause onset; yet direct evidence of effects on ovarian function is lacking. Environmental contaminant concentrations have been quantified in human ovarian follicular fluid establishing target tissue exposure; however, such data is sporadic and limited to women undergoing assisted reproductive therapies making generalization of results to the broader population of women difficult. We note that the relationship between serum and follicular fluid concentrations can be orders of magnitude different and thus target tissue distribution requires further study. Animal studies revealed effects of environmental contaminants on ovarian follicle dynamics, oocyte maturation, steroidogenesis, and epigenetic changes. Issues of dosing such as concentration of test chemicals used, route of administration, and use of multiple dose groups remain important limitations of the current literature. While animal studies establish a basis for biological plausibility of effects and support conclusions of reproductive hazard, we conclude that exposures in the general human population are too low to present a demonstrable risk to human ovarian function.es_ES
Doihttps://doi.org/10.1007/978-3-319-27449-2_7es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6080
Idiomaenes_ES
EditorialSpringer Science+Business Media B.V.es_ES
RelaciónMolecular and Integrative Toxicologyes_ES
URL relacionadohttps://doi.org/10.1007/978-3-319-27449-2_7es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMolecular and Integrative Toxicology
Palabra claveChemical contaminantses_ES
Palabra claveOvaryes_ES
Palabra claveSteroidogenesises_ES
Palabra claveToxicantses_ES
Palabra claveToxicologyes_ES
TítuloOvarian toxicity of environmental contaminants: 50 shades of greyes_ES
TipoCapítulo Libroes_ES
ArbitradoHa sido Arbitradoes_ES
AutorDominguez, M.A.
AutorSadeu, J.C.
AutorGuerra, M.T.
AutorFurlong, H.C.
AutorBaines, Sharnjit
AutorFoster, Warren G.
AutorDominguez, M.A.es_ES
AutorSadeu, J.C.es_ES
AutorGuerra, M.T.es_ES
AutorFurlong, H.C.es_ES
AutorBaines, Sharnjites_ES
AutorFoster, Warren G.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas215-244es_ES
URL relacionadahttps://doi.org/10.1007/978-3-319-27449-2_7
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES

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