Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:44Z
Fecha de publicación2025-01-01
ResumenPain management requires the identification of certain indicators to recognize pain. Various tools have been suggested to achieve an objective evaluation, including infrared thermography (IRT). The objective of this study was to assess the facial thermal nociceptive response produced by the use of cannabidiol (CBD) alone and in combination with meloxicam in female dogs undergoing elective ovariohysterectomy anesthetized with isoflurane. Sixty-four female dogs of different breeds were randomly distributed into four study groups according to the treatment received. G1: Placebo group (n = 16); G2: Group receiving intravenous meloxicam as premedication (0.2 mg Kg(-1)) and every 24 h postoperatively 0.1 mg Kg(-1) (n = 16); G3: Group treated with CBD (n = 16) at a dose of 2 mg kg(-1) orally every 12 h; and G4: Group medicated with the combination of both treatments (n = 16). All treatments were administered for 48 h postoperatively. After the anesthetic surgical procedure, radiometric images were captured using IRT and physiological parameters during the events E-Basal, E-30min, E-1h, E-2h, E-3h, E-4h, E-8h, E-12h, E-24h and E-48h. Overall, it was found that the high, medium and low temperatures of the thermal windows of the eye, upper eyelid and lower eyelid, as well as the average temperature of the lacrimal gland in G1 between events, were significantly lower at E-30min, E-1h and E-2h compared to E-Basal (p = 0.01). Among treatments, a significantly higher temperature was observed in groups G2, G3 and G4 compared to G1 (p = 0.001) in the thermal windows of the upper eyelid, lower eyelid, lacrimal gland and ocular areas. Regarding physiological parameters, heart rate (HR) was higher in G1 compared to the animals in G2, G3 and G4 (p = 0.03). The respiratory rate (RR) was significantly lower in all four study groups during the postoperative events compared to their respective E-Basal (p < 0.05), while among treatments, G2, G3 and G4 had a lower RR compared to G1 (p = 0.03). Mild hypothermia was observed in all study groups at E-30min and E-1h compared to E-Basal (p = 0.001). No significant correlation was found between the temperatures of the assessed thermal regions and the physiological traits. In conclusion, CBD, whether administered alone or in combination with meloxicam, demonstrated comparable analgesic efficacy, which could control nociceptive cardiorespiratory and hemodynamic autonomic responses, as there were no significant changes in the facial thermal response between treatments G2, G3 and G4.es_ES
Doihttps://doi.org/10.3390/ani15020227es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4580
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónAnimalses_ES
URL relacionadohttps://doi.org/10.3390/ani15020227es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteAnimals
Palabra clavedogses_ES
Palabra clavepaines_ES
Palabra claveinfrared thermographyes_ES
Palabra clavecannabises_ES
Palabra claveanalgesiaes_ES
TítuloAssessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesiaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCasas-Alvarado, Alejandro
AutorMora-Medina, Patricia
AutorHernandez-Avalos, Ismael
AutorMartinez-Burnes, Julio
AutorMiranda-Cortes, Agatha
AutorDominguez-Oliva, Adriana
AutorMota-Rojas, Daniel
AutorCasas-Alvarado, Alejandroes_ES
AutorMora-Medina, Patriciaes_ES
AutorHernandez-Avalos, Ismaeles_ES
AutorMartinez-Burnes, Julioes_ES
AutorMiranda-Cortes, Agathaes_ES
AutorDominguez-Oliva, Adrianaes_ES
AutorMota-Rojas, Danieles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
URL relacionadahttps://doi.org/10.3390/ani15020227
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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