Antioxidant and Antiproliferative Activity of the Ethanolic Extract of Equisetum myriochaetum and Molecular Docking of Its Main Metabolites (Apigenin, Kaempferol, and Quercetin) on β-Tubulin
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-09-15T00:30:09Z | |
| Fecha de publicación | 2021-01-01 | |
| Resumen | Equisetum myriochaetum is a semi-aquatic plant found on riverbanks that is commonly used in traditional medicine as a diuretic agent. Additionally, the genus Equisetum stands out for its content of the flavonoid kaempferol, a well-known antiproliferative agent. Therefore, in this study, E. myriochaetum ethanolic extract was tested in vitro against a cervical cancer cell line (SiHa). Additionally, the antioxidative activity was evaluated through a 2,2-diphenyl-1-picrilhidrazil (DPPH) assay. Finally, a molecular docking analysis of apigenin, kaempferol, and quercetin on the active site of β-tubulin was performed to investigate their potential mechanism of action. All fractions of E. myriochaetum ethanolic extract showed antioxidative activity. Fraction 14 displayed an antiproliferative capacity with a half maximal inhibitory concentration (IC50) value of 6.78 μg/mL against SiHa cells. | es_ES |
| Doi | https://doi.org/10.3390/molecules26020443 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/2106 | |
| Idioma | es | es_ES |
| Editorial | MDPI AG | es_ES |
| Relación | Molecules | es_ES |
| URL relacionado | https://doi.org/10.3390/molecules26020443 | es_ES |
| Derechos | Acceso abierto (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_abf2 | es_ES |
| Fuente | Molecules | |
| Título | Antioxidant and Antiproliferative Activity of the Ethanolic Extract of Equisetum myriochaetum and Molecular Docking of Its Main Metabolites (Apigenin, Kaempferol, and Quercetin) on β-Tubulin | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | Olazarán-Santibañez, Fabián | |
| Autor | Rivera, Gildardo | |
| Autor | Vanoye-Eligio, Venancio | |
| Autor | Mora-Olivo, Arturo | |
| Autor | Aguirre-Guzmán, Gabriel | |
| Autor | Ramírez-Cabrera, Mónica | |
| Autor | Arredondo-Espinoza, Eder | |
| Autor | Olazarán-Santibañez, Fabián | es_ES |
| Autor | Rivera, Gildardo | es_ES |
| Autor | Vanoye-Eligio, Venancio | es_ES |
| Autor | Mora-Olivo, Arturo | es_ES |
| Autor | Aguirre-Guzmán, Gabriel | es_ES |
| Autor | Ramírez-Cabrera, Mónica | es_ES |
| Autor | Arredondo-Espinoza, Eder | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Número | 2 | es_ES |
| Rango de páginas | 443 | es_ES |
| URL relacionada | https://doi.org/10.3390/molecules26020443 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 26 | es_ES |