Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:08Z
Fecha de publicación2006-01-01
ResumenMontero, Sergio, Heron Mendoza, Victoria Valles, Monica Lemus, Ramon Alvarez-Buylla, and Elena R. de Alvarez-Buylla. Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide. J Appl Physiol 100: 1902-1909, 2006. First published February 23, 2006; doi: 10.1152/japplphysiol. 01414.2005. - Hypoxic stimulation of the carotid body receptors (CBR) results in a rapid hyperglycemia with an increase in brain glucose retention. Previous work indicates that neurohypophysectomy inhibits this hyperglycemic response. Here, we show that systemic arginine vasopressin (AVP) induced a transient, but significant, increase in blood glucose levels and increased brain glucose retention, a response similar to that observed after CBR stimulation. Comparable results were obtained after intracerebral infusion of AVP. Systemic AVP-induced changes were maintained in hypophysectomized rats but were not observed after adrenalectomy. Glycemic changes after CBR stimulation were inhibited by pharmacological blockage of AVP V1a receptors with a V1a-selective receptor antagonist ({[}beta-Mercapto- beta,beta-cyclopentamethylenepropionyl(1), Ome-Tyr(2), Arg(8)]-vasopressin). Importantly, local application of micro-doses of this antagonist to the liver was sufficient to abolish the hyperglycemic response after CBR stimulation. These results suggest that AVP is a mediator of the hyperglycemic reflex and cerebral glucose retention following CBR stimulation. We propose that hepatic activation of AVP V1a receptors is essential for this hyperglycemic response.es_ES
Doihttps://doi.org/10.1152/japplphysiol.01414.2005es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4975
Idiomaenes_ES
EditorialAMER PHYSIOLOGICAL SOCes_ES
RelaciónJournal of Applied Physiologyes_ES
URL relacionadohttps://doi.org/10.1152/japplphysiol.01414.2005es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Applied Physiology
Palabra clavechemoreceptorses_ES
Palabra clavecentral nervous system respirationes_ES
TítuloArginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanidees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMontero, Sergio
AutorMendoza, Heron
AutorValles, Victoria
AutorLemus, Monica
AutorAlvarez-Buylla, Ramon
Autorde Alvarez-Buylla, Elena R.
AutorMontero, Sergioes_ES
AutorMendoza, Herones_ES
AutorValles, Victoriaes_ES
AutorLemus, Monicaes_ES
AutorAlvarez-Buylla, Ramones_ES
Autorde Alvarez-Buylla, Elena R.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número6es_ES
Rango de páginas1902-1909es_ES
URL relacionadahttps://doi.org/10.1152/japplphysiol.01414.2005
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen100es_ES

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