Impact of gestational diabetes mellitus in gut and human breast milk microbiome in Colombian women and their infants

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:06Z
Fecha de publicación2025-01-01
ResumenHuman breast milk (HBM) is a vital source of macronutrients and micronutrients that are crucial for an infant's development. Recent studies have shown that HBM contains diverse microorganisms, including bacteria, viruses, protozoa, and anaerobic fungi. Additionally, novel research has revealed that individuals with metabolic disorders, such as diabetes mellitus, are prone to dysbiosis in their gut microbiome. Our study aimed to investigate the impact of gestational diabetes mellitus (GDM) on HBM and the pair mother-infant gut microbiota. We conducted a comprehensive analysis of two groups from Pereira, Colombia: a GDM group and a non-GDM group. Each group consisted of five infants and their mothers. HBM and stool samples were collected from GDM and non-GDM mother-infant pairs. DNA was purified, and the 16S V3-V4 region was amplified and sequenced. Reads obtained were quality filtered and classified by homology according to the Ribosomal Small Subunit SILVA database. We found significant differences in the relative abundances of gut bacteria between GDM and non-GDM groups. Notably, Bifidobacterium, Serratia and Sutterella were negatively associated in women's gut with GDM. In HBM, Sutterella, Serratia and Lactococcus were found in low RA in the GDM group. Moreover, in the infants, Bifidobacterium, Lactobacillus, Sutterella, Serratia, Streptococcus, and Veillonella had a low presence in GDM. Our findings indicate that there are variations in gut bacteriome profiles between healthy women and those with GDM. These variations may impact the bacterial diversity in HBM, potentially leading to gut bacterial dysbiosis in their infants. (c) 2024 The Authors. Published by Elsevier Espana, S.L.U. on behalf of Asociacio<acute accent>n Argentina de Microbiolog<acute accent>\& imath;a. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).es_ES
Doihttps://doi.org/10.1016/j.ram.2024.10.006es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4911
Idiomaenes_ES
EditorialASOCIACION ARGENTINA MICROBIOLOGIAes_ES
RelaciónRevista Argentina de Microbiologiaes_ES
URL relacionadohttps://doi.org/10.1016/j.ram.2024.10.006es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteRevista Argentina de Microbiologia
Palabra claveBacteriomees_ES
Palabra claveGestational diabetes mellituses_ES
Palabra claveBreast milkes_ES
Palabra claveBreastfeedinges_ES
TítuloImpact of gestational diabetes mellitus in gut and human breast milk microbiome in Colombian women and their infantses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorValencia-Castillo, Sandra Y.
AutorHernandez-Beza, Mayte J.
AutorPowell-Cerda, Irisbeth
AutorAcosta-Cruz, Erika
AutorRodriguez-Castillejos, Guadalupe C.
AutorSiller-Lopez, Fernando
AutorMartinez-Montoya, Humberto
AutorValencia-Castillo, Sandra Y.es_ES
AutorHernandez-Beza, Mayte J.es_ES
AutorPowell-Cerda, Irisbethes_ES
AutorAcosta-Cruz, Erikaes_ES
AutorRodriguez-Castillejos, Guadalupe C.es_ES
AutorSiller-Lopez, Fernandoes_ES
AutorMartinez-Montoya, Humbertoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas14-23es_ES
URL relacionadahttps://doi.org/10.1016/j.ram.2024.10.006
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen57es_ES

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