Potential vascular α1-adrenoceptor blocking properties of metformin in rat aorta and tail artery

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:15Z
Fecha de publicación2019-01-01
ResumenMetformin is a widely used drug for the treatment of type 2 Diabetes Mellitus. Several studies have also suggested that metformin decreases blood pressure; although an interaction with alpha(1)-adrenoceptors has been proposed, this mechanism needs to be further investigated. Since alpha(1)-adrenoceptors play a significant role to regulate vascular tone, this study has analysed the potential ability of metformin to block alpha(1-)adrenoceptors in rat aorta and tail artery. For this purpose, the contractile responses induced by noradrenaline, methoxamine, and phenylephrine were determined in the absence or presence of metformin in rat aorta and tail artery rings. In both arteries, noradrenaline, methoxamine, and phenylephrine produced concentration-dependent contractile responses. Interestingly, the contractile responses to noradrenaline, methoxamine, and phenylephrine were significantly and differentially blocked by metformin (1, 3.1 and/or 10 mM) but not by vehicle. These results suggest that metformin is capable to block alpha(1)-adrenoceptors and may explain, at least in part, the anti-hypertensive effect observed in several clinical trials.es_ES
Doihttps://doi.org/10.1016/j.ejphar.2019.172498es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5086
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónEuropean Journal of Pharmacologyes_ES
URL relacionadohttps://doi.org/10.1016/j.ejphar.2019.172498es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteEuropean Journal of Pharmacology
Palabra clavealpha(1)-adrenoceptorses_ES
Palabra clavePhenylephrinees_ES
Palabra claveMethoxaminees_ES
Palabra claveNoradrenalinees_ES
Palabra claveMetformines_ES
TítuloPotential vascular α1-adrenoceptor blocking properties of metformin in rat aorta and tail arteryes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlvarez-Camara, Jose F.
AutorRamirez-Rosas, Martha B.
AutorMedina-Terol, Grecia J.
AutorSilva-Velasco, Diana L.
AutorVelazco-Paz, Andrea
AutorSanchez-Lopez, Araceli
AutorGuzman-Priego, Crystell G.
AutorOsuna-Martinez, Ulises
AutorCenturion, David
AutorAlvarez-Camara, Jose F.es_ES
AutorRamirez-Rosas, Martha B.es_ES
AutorMedina-Terol, Grecia J.es_ES
AutorSilva-Velasco, Diana L.es_ES
AutorVelazco-Paz, Andreaes_ES
AutorSanchez-Lopez, Aracelies_ES
AutorGuzman-Priego, Crystell G.es_ES
AutorOsuna-Martinez, Uliseses_ES
AutorCenturion, Davides_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.1016/j.ejphar.2019.172498
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen858es_ES

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