Osteogenic Pain: A "Novel" Concept Based on Rodent and Human Studies.

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:41Z
Fecha de publicación2026-07-01
ResumenBACKGROUND: The chronic bone pain associated with various skeletal conditions poses significant challenges to clinical management. Current treatments, which often rely on systemic opioids, come with adverse effects, emphasizing the need for safer alternatives. Understanding the neurobiology of bone pain and exploring novel therapeutic avenues for the condition are critical for improving patient outcomes. OBJECTIVES: This review aims to examine recent preclinical studies elucidating the mechanisms underlying bone pain and to propose an innovative concept, known herein as osteogenic pain, to aid in relieving it. STUDY DESIGN: A comprehensive review of preclinical studies investigating bone pain mechanisms and treatment approaches was conducted. Literature focusing on the interaction between neurons and bone microenvironment cells was examined, as was literature concerning the development of nonopioid analgesics targeting peripheral processes. RESULTS: This review highlights the intricate interactions among neurons, immune cells, osteoclasts, and osteoblasts within the bone microenvironment that contribute to the pathophysiology of bone pain. The study identifies the increased excitability of primary afferent neurons as a crucial factor in bone pain development, and a new concept of osteogenic pain is proposed. LIMITATIONS: The translation of preclinical findings to clinical settings requires further validation, highlighting the need for more clinically relevant animal models and experimental methods. CONCLUSION: The proposal of "osteogenic pain" as a new concept underscores the need for improved clinical methods of treating bone pain and validated tools for the assessment and diagnosis thereof. The future of bone pain management lies in exploration, including targeting peripheral processes and leveraging innovative therapies, interventional techniques, and inclusive integration of artificial intelligence into them. Through new tools for assessment and monitoring, these efforts may provide patients who have bone disorders with better pain relief and improved quality of life.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/3366
Idiomaenes_ES
EditorialNational Institutes of Healthes_ES
RelaciónPubMedes_ES
URL relacionadohttps://pubmed.ncbi.nlm.nih.gov/42550521es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuentePubMed
Palabra claveChronic paines_ES
Palabra claveTranslational researches_ES
Palabra claveImmune systemes_ES
Palabra claveBone celles_ES
Palabra claveBone paines_ES
Palabra claveOsteoporosises_ES
Palabra claveAdverse effectes_ES
Palabra claveBone remodelinges_ES
Palabra claveBone formationes_ES
ClasificaciónPain Mechanisms and Treatmentses_ES
TítuloOsteogenic Pain: A "Novel" Concept Based on Rodent and Human Studies.es_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPlancarte, Ricard
AutorDiwan, Sudhir
AutorAbd-Elsayed, Alaa A
AutorSarzaeim, Mojdeh
AutorHernandez-Porras, B Carolina
AutorJiménez‐Andrade, Juan Miguel
AutorPlancarte, Ricardes_ES
AutorDiwan, Sudhires_ES
AutorAbd-Elsayed, Alaa Aes_ES
AutorSarzaeim, Mojdehes_ES
AutorHernandez-Porras, B Carolinaes_ES
AutorJiménez‐Andrade, Juan Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
Rango de páginasE363-E374es_ES
URL relacionadahttps://pubmed.ncbi.nlm.nih.gov/42550521
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen29es_ES

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