XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:29Z
Fecha de publicación2009-01-01
ResumenWe examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain reaction. No significant differences in allele and genotype frequencies for any polymorphism were observed between patients and controls. Estimation of haplotypes showed the eight expected haplotypes (A-H), seven of which were found in both patients and controls; haplotype A (Arg-Arg-Arg) was the most common, whereas haplotypes F and G were absent in patients and controls, respectively. Haplotype B (Trp-Arg-Arg) was found to be associated with an increased risk of ALL (odds ratio (OR) = 1.95, 95% confidence interval (CI) = 1.13-3.37; P = 0.016), particularly in males (OR = 2.65, 95%CI = 1.25-5.63; P = 0.01). Individually, the 194Trp, 280His, and 399Gln alleles were not associated with significantly increased risk for ALL in these Mexican children.es_ES
Doihttps://doi.org/10.4238/vol8-4gmr687es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6276
Idiomaenes_ES
RelaciónGenetics and Molecular Researches_ES
URL relacionadohttps://doi.org/10.4238/vol8-4gmr687es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteGenetics and Molecular Research
Palabra claveChildhood acute lymphoblastic leukemiaes_ES
Palabra claveHaplotypeses_ES
Palabra claveMexicanses_ES
Palabra clavePolymorphismses_ES
Palabra claveXRCC1es_ES
TítuloXRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemiaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMeza-Espinoza, J.P.
AutorPeralta-Leal, V.
AutorGutierrez-Angulo, M.
AutorMacias-Gomez, N.
AutorAyala-Madrigal, M.L.
AutorBarros-Nuñez, P.
AutorDuran-Gonzalez, J.
AutorLeal-Ugarte, E.
AutorMeza-Espinoza, J.P.es_ES
AutorPeralta-Leal, V.es_ES
AutorGutierrez-Angulo, M.es_ES
AutorMacias-Gomez, N.es_ES
AutorAyala-Madrigal, M.L.es_ES
AutorBarros-Nuñez, P.es_ES
AutorDuran-Gonzalez, J.es_ES
AutorLeal-Ugarte, E.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas1451-1458es_ES
URL relacionadahttps://doi.org/10.4238/vol8-4gmr687
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen8es_ES

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