High‐fat diet exacerbates pain‐like behaviors and periarticular bone loss in mice with CFA‐induced knee arthritis

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:01Z
Fecha de publicación2016-01-01
ResumenObjectiveOur aim was to quantify nociceptive spontaneous behaviors, knee edema, proinflammatory cytokines, bone density, and microarchitecture in high‐fat diet (HFD)‐fed mice with unilateral knee arthritis.MethodsICR male mice were fed either standard diet (SD) or HFD starting at 3 weeks old. At 17 weeks, HFD and SD mice received intra‐articular injections either with Complete Freund's Adjuvant (CFA) or saline into the right knee joint every 7 days for 4 weeks. Spontaneous pain‐like behaviors and knee edema were assessed for 26 days. At day 26 post‐first CFA injection, serum levels of IL‐1β, IL‐6, and RANKL were measured by ELISA, and microcomputed tomography analysis of knee joints was performed.ResultsHFD‐fed mice injected with CFA showed greater spontaneous pain‐like behaviors of the affected extremity as well as a decrease in the weight‐bearing index compared to SD‐fed mice injected with CFA. Knee edema was not significantly different between diets. HFD significantly exacerbated arthritis‐induced bone loss at the distal femoral metaphysis but had no effect on femoral diaphyseal cortical bone. HFD did not modify serum levels of proinflammatory cytokines.ConclusionsHFD exacerbates pain‐like behaviors and significantly increases the magnitude of periarticular trabecular bone loss in a murine model of unilateral arthritis.es_ES
Doihttps://doi.org/10.1002/oby.21485es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1953
Idiomaeses_ES
EditorialWileyes_ES
RelaciónObesityes_ES
URL relacionadohttps://doi.org/10.1002/oby.21485es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteObesity
TítuloHigh‐fat diet exacerbates pain‐like behaviors and periarticular bone loss in mice with CFA‐induced knee arthritises_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLoredo‐Pérez, Aleyda A.
AutorMontalvo‐Blanco, Carlos E.
AutorHernández‐González, Luis I.
AutorAnaya‐Reyes, Maricruz
AutorValle‐Laisequilla, Cecilia Fernández del
AutorReyes‐García, Juan G.
AutorAcosta‐González, Rosa I.
AutorMartínez‐Martínez, Arisai
AutorVillarreal‐Salcido, Jaira C.
AutorVargas‐Muñoz, Virginia M.
AutorMuñoz‐Islas, Enriqueta
AutorRamírez‐Rosas, Martha B.
AutorJiménez‐Andrade, Juan M.
AutorLoredo‐Pérez, Aleyda A.es_ES
AutorMontalvo‐Blanco, Carlos E.es_ES
AutorHernández‐González, Luis I.es_ES
AutorAnaya‐Reyes, Maricruzes_ES
AutorValle‐Laisequilla, Cecilia Fernández deles_ES
AutorReyes‐García, Juan G.es_ES
AutorAcosta‐González, Rosa I.es_ES
AutorMartínez‐Martínez, Arisaies_ES
AutorVillarreal‐Salcido, Jaira C.es_ES
AutorVargas‐Muñoz, Virginia M.es_ES
AutorMuñoz‐Islas, Enriquetaes_ES
AutorRamírez‐Rosas, Martha B.es_ES
AutorJiménez‐Andrade, Juan M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
Rango de páginas1106-1115es_ES
URL relacionadahttps://doi.org/10.1002/oby.21485
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen24es_ES

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