Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica

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AudienciaPúblico en generales_ES
CoberturaMéxico[ 143]es_ES
Fecha de ingreso2026-10-05T16:34:49Z
Fecha de publicación2006-01-01
ResumenLactoferrin (Lf), in its iron-free form, has been shown to inhibit the growth of pathogenic microorganisms. In the light of new agents to control amoebiasis, the microbicidal activity of human and bovine Lf and bovine lactoferricin (bLfcin, fragment 4-14), and of each combined with metronidazole, the main drug used in amoebiasis, was evaluated in trophozoites of Entamoeba histolytica. Both lactoferrins and bLfcin were able to kill amoebas in a concentration-dependent manner. This killing effect was modulated according to the culture age, pH, and temperature. Parasites obtained from the stationary phase were more susceptible to Lf than those from the early exponential phase. The effect of Lf and its derived peptide, bLfcin, was prevented by both Fe2+ and Fe3+. However, the divalent cations Mg2+ and Ca2+ prevented the killing effect of Lf but not of bLfcin. A synergistic amoebicidal effect was found between metronidazole and human Lf, bovine Lf, or bLfcin. These data suggest that Lf and bLfcin might be used in amoebiasis if they are administered with a low dose of metronidazole to diminish the toxicity of this drug. Thus, Lf and bLfcin are therapeutically potential candidates for use as antiamoebics in patients.es_ES
Doihttps://doi.org/10.1139/o06-060es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6304
IdiomaInglés[20]es_ES
EditorialCANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESSes_ES
RelaciónBiochemistry and Cell Biologyes_ES
URL relacionadohttps://doi.org/10.1139/o06-060es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteBiochemistry and Cell Biology
Palabra claveEntamoeba histolyticaes_ES
Palabra claveamoebicidales_ES
Palabra clavelactoferrines_ES
Palabra clavelactoferricines_ES
Palabra clavemetronidazolees_ES
Palabra claveparasitees_ES
Palabra clavesynergyes_ES
TítuloMicrobicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolyticaes_ES
TipoPonenciaes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLeon-Sicairos, Nidia
AutorReyes-Lopez, Magda
AutorOrdaz-Pichardo, Cynthia
Autorde la Garza, Mireya
AutorLeon-Sicairos, Nidiaes_ES
AutorReyes-Lopez, Magdaes_ES
AutorOrdaz-Pichardo, Cynthiaes_ES
Autorde la Garza, Mireyaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas327-336es_ES
URL relacionadahttps://doi.org/10.1139/o06-060
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen84es_ES

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