Association of the SLC6A4 gene 5HTTLPR polymorphism and ADHD with epilepsy, gestational diabetes, and parental substance abuse in Mexican mestizo children

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:55Z
Fecha de publicación2018-01-01
ResumenIntroduction. Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric conditions in childhood and a multifactorial condition attributable to genetic and/or environmental influence. Allelic variants in the serotonin transporter gene (SLC6A4) have been associated to lower transcriptional efficiency, changes in serotonin concentration in several brain regions, and ADHD development. Objective. To identify the association between the SLC6A4 alleles and ADHD diagnosis and risk factor phenotypes in children from a Mexican mestizo population. Method. In this study, 134 unrelated children were included and evaluated for ADHD, genotypification for the 5HTTLPR polymorphism, and identification of multiple phenotypes from their clinical records and family background for association analysis. Results. The following distribution of genotypes was observed: 23\% SS, 49\% SL, and 28\% LL. From the phenotypes evaluated in the present study, gestational diabetes mellitus (p = .045), history of epilepsy (p = .047), and parental substance abuse (p = .033) showed an association with ADHD development in regression analysis along with the S variant. Discussion and conclusion. Results suggest that interaction of the S allele and some of the phenotypes analyzed may play a relevant role in the development of ADHD in the studied population.es_ES
Doihttps://doi.org/10.17711/sm.0185-3325.2018.033es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4752
Idiomaenes_ES
EditorialINST NAC PSIQUIATRIA RAMON FUENTE MUNIZes_ES
RelaciónSalud Mentales_ES
URL relacionadohttps://doi.org/10.17711/sm.0185-3325.2018.033es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteSalud Mental
Palabra claveSerotonin transporteres_ES
Palabra claveattention deficit hyperactivity disorderes_ES
Palabra claveSLC6A4 genees_ES
Palabra claveallelees_ES
TítuloAssociation of the SLC6A4 gene 5HTTLPR polymorphism and ADHD with epilepsy, gestational diabetes, and parental substance abuse in Mexican mestizo childrenes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorDuran-Gonzalez, Jorge
AutorLeal-Ugarte, Evelia
AutorEleazar Cruz-Alcala, Leonardo
AutorGutierrez-Angulo, Melva
AutorPatricia Gallegos-Arreola, Martha
AutorMeza-Espinoza, Juan Pablo
AutorReyes-Zurita, Itzayana
AutorLizbeth Padilla-Macias, Patricia
AutorCruz-Martin del Campo, Edgar
AutorPeralta-Leal, Valeria
AutorDuran-Gonzalez, Jorgees_ES
AutorLeal-Ugarte, Eveliaes_ES
AutorEleazar Cruz-Alcala, Leonardoes_ES
AutorGutierrez-Angulo, Melvaes_ES
AutorPatricia Gallegos-Arreola, Marthaes_ES
AutorMeza-Espinoza, Juan Pabloes_ES
AutorReyes-Zurita, Itzayanaes_ES
AutorLizbeth Padilla-Macias, Patriciaes_ES
AutorCruz-Martin del Campo, Edgares_ES
AutorPeralta-Leal, Valeriaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
Rango de páginas223-236es_ES
URL relacionadahttps://doi.org/10.17711/sm.0185-3325.2018.033
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen41es_ES

Files

Collections

Documentación Cientifica