Analysis of nonsynonymous SNPs in candidate genes that influence bovine temperament and evaluation of their effect in Brahman cattle

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:37Z
Fecha de publicación2024-01-01
ResumenBackgroundTemperament is an important production trait in cattle and multiple strategies had been developed to generate molecular markers to assist animal selection. As nonsynonymous single nucleotide polymorphisms are markers with the potential to affect gene functions, they could be useful to predict phenotypic effects. Genetic selection of less stress-responsive, temperamental animals is desirable from an economic and welfare point of view.Methods and resultsTwo nonsynonymous single nucleotide polymorphisms identified in HTR1B and SLC18A2 candidate genes for temperament were analyzed in silico to determine their effects on protein structure. Those nsSNPs allowing changes in proteins were selected for a temperament association analysis in a Brahman population. Transversion effects on protein structure were evaluated in silico for each amino acid change model, revealing structural changes in the proteins of the HTR1B and SLC18A2 genes. The selected nsSNPs were genotyped in a Brahman population (n = 138), and their genotypic effects on three temperament traits were analyzed: exit velocity, pen score, and temperament score. Only the SNP rs209984404-HTR1B (C/A) showed a significant association (P = 0.0144) with pen score. The heterozygous genotype showed a pen score value 1.17 points lower than that of the homozygous CC genotype.ConclusionThe results showed that in silico analysis could direct the selection of nsSNPs with the potential to change the protein. Non-synonymous single nucleotide polymorphisms causing structural changes and reduced protein stability were identified. Only rs209984404-HTR1B shows that the allele affecting protein stability was associated with the genotype linked to docility in cattle.es_ES
Doihttps://doi.org/10.1007/s11033-024-09264-4es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5406
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónMolecular Biology Reportses_ES
URL relacionadohttps://doi.org/10.1007/s11033-024-09264-4es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMolecular Biology Reports
Palabra claveBehaviores_ES
Palabra claveCandidate geneses_ES
Palabra claveModellinges_ES
Palabra claveAmino acid changees_ES
Palabra claveSerotonin receptores_ES
TítuloAnalysis of nonsynonymous SNPs in candidate genes that influence bovine temperament and evaluation of their effect in Brahman cattlees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRuiz-De-La-Cruz, Gilberto
AutorSifuentes-Rincon, Ana Maria
AutorParedes-Sanchez, Francisco Alejandro
AutorParra-Bracamonte, Gaspar Manuel
AutorCasas, Eduardo
AutorRiley, David G.
AutorPerry, George A.
AutorWelsh Jr, Thomas H.
AutorRandel, Ronald D.
AutorRuiz-De-La-Cruz, Gilbertoes_ES
AutorSifuentes-Rincon, Ana Mariaes_ES
AutorParedes-Sanchez, Francisco Alejandroes_ES
AutorParra-Bracamonte, Gaspar Manueles_ES
AutorCasas, Eduardoes_ES
AutorRiley, David G.es_ES
AutorPerry, George A.es_ES
AutorWelsh Jr, Thomas H.es_ES
AutorRandel, Ronald D.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1007/s11033-024-09264-4
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen51es_ES

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