Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:24Z
Fecha de publicación2021-01-01
ResumenPurpose: Gestational diabetes mellitus (GDM) induces cardiovascular and metabolic disturbances in offspring. However, the effects of GDM in pain processing in offspring and whether male and female offspring are equally affected is not well known. Thus, we determined: i) whether GDM in mice affects offspring hindpaw mechanical sensitivity, capsaicin-induced spontaneous pain-like behaviors, and epidermal nerve fiber density (ENFD); and ii) whether there is sexual dimorphism in these parameters in offspring from GDM dams. Methods: GDM was induced in pregnant ICR mice via i.p. streptozotocin (STZ). Then, glucose levels from dams and offspring were determined. Male and female offspring 2-3 months of age were evaluated for: a) baseline mechanical sensitivity of the hind paw by using von Frey filaments; b) number of flinches and time spent guarding induced by intraplantar capsaicin (0.1\%); and c) density of PGP-9.5 and CGRP axons in the epidermis from the hind paw glabrous skin. Results: Prepartum levels of glucose in STZ-treated dams were significantly increased compared to vehicle-treated dams; however, GDM or vehicle offspring displayed normal and similar blood glucose levels. Male and female GDM offspring showed significantly greater mechanical sensitivity and capsaicin-induced pain behaviors compared to vehicle offspring. Male GDM offspring displayed a slightly more intense nociceptive phenotype in the capsaicin test. PGP-9.5 and CGRP ENFD in hind paw glabrous skin were greater in male and female GDM offspring versus their controls. Sexual dimorphism was generally not observed in GDM offspring in most of the studied parameters. Conclusion: These results suggest GDM induced greater pain-like behaviors in adult offspring regardless of sex along with an increased ENFD of PGP-9.5 and CGRP in the hind paw glabrous skin. We show that GDM peripheral neuropathy differs from diabetic peripheral neuropathy acquired in adulthood and set the foundation to further study this in human babies exposed to GDM.es_ES
Doihttps://doi.org/10.2147/jpr.s313467es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5207
Idiomaenes_ES
EditorialDOVE MEDICAL PRESS LTDes_ES
RelaciónJournal of Pain Researches_ES
URL relacionadohttps://doi.org/10.2147/jpr.s313467es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Pain Research
Palabra claveoffspringes_ES
Palabra clavelong-term effectses_ES
Palabra clavenociceptiones_ES
Palabra claveCGRPes_ES
TítuloEffect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspringes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMunoz-Islas, Enriqueta
AutorEsther Elizondo-Martinez, Cecilia
AutorGutierrez-Lopez, Mariela
AutorIssel Acosta-Gonzalez, Rosa
AutorZaga-Clavellina, Veronica
AutorCecilia Helguera-Repetto, Addy
AutorBeatriz Ramirez-Rosas, Martha
AutorAlfonso Romero-Sandoval, E.
AutorMiguel Jimenez-Andrade, Juan
AutorMunoz-Islas, Enriquetaes_ES
AutorEsther Elizondo-Martinez, Ceciliaes_ES
AutorGutierrez-Lopez, Marielaes_ES
AutorIssel Acosta-Gonzalez, Rosaes_ES
AutorZaga-Clavellina, Veronicaes_ES
AutorCecilia Helguera-Repetto, Addyes_ES
AutorBeatriz Ramirez-Rosas, Marthaes_ES
AutorAlfonso Romero-Sandoval, E.es_ES
AutorMiguel Jimenez-Andrade, Juanes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas1573-1585es_ES
URL relacionadahttps://doi.org/10.2147/jpr.s313467
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen14es_ES

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