Emotional pain in non-human mammals: from neural circuitry and opioid signaling to dysthymia-like states, grief-like behaviors, and physiological dysregulation

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2026-01-01
ResumenThis review aims to analyze the neurobiological, pathophysiological, and ethological foundations of emotional pain in non-human mammals, with particular emphasis on the transition from adaptive responses to pathological states such as animal dysthymia and Takotsubo syndrome. In the review, four conditions that can activate emotional systems will be discussed, such as pain derived from surgery or injury, stressful conditions that do not cause pain (e.g., unknown noises or smells), separation stress where an animal is isolated from the group (e.g., dam-calf separation), and death of a familiar animal or conspecific. The review will examine the role of subcortical brain regions, highlighting the amygdala-particularly the basolateral complex and central nucleus-as key integrators of negative affect and stress responses. In addition, it will address the contribution of cortical regions, such as the anterior cingulate cortex, and their interaction with the endogenous opioid system in the processing of affective suffering. The review will also incorporate evidence of thanatological behaviors and mourning-like responses, suggesting a degree of death awareness and social sensitivity to loss across multiple species. While the function of these neural circuits is fundamentally adaptive, chronic activation may induce neuroplastic changes and neurotransmitter dysregulation, leading to maladaptive outcomes. These include persistent anxiety, depression-like states, thanatological behaviors, and stress-related cardiac conditions such as Takotsubo syndrome, all of which may compromise animal welfare. Finally, further comparative research is needed to deepen our understanding of emotional pain in non-human animals.es_ES
Doihttps://doi.org/10.3389/fvets.2026.1878991es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5446
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Veterinary Sciencees_ES
URL relacionadohttps://doi.org/10.3389/fvets.2026.1878991es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Veterinary Science
Palabra clavedysthymiaes_ES
Palabra claveemotional paines_ES
Palabra clavegrief-like behaviores_ES
Palabra clavepanices_ES
Palabra clavethanatological behaviorses_ES
TítuloEmotional pain in non-human mammals: from neural circuitry and opioid signaling to dysthymia-like states, grief-like behaviors, and physiological dysregulationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMota-Rojas, Daniel
AutorWhittaker, Alexandra L.
AutorCoria-Avila, Genaro A.
AutorHernandez-Avalos, Ismael
AutorMartinez-Burnes, Julio
AutorDominguez-Oliva, Adriana
AutorOlmos-Hernandez, Adriana
AutorTorres-Bernal, Fabiola
AutorReyes-Sotelo, Brenda
AutorMiranda-Cortes, Agatha
AutorCasas-Alvarado, Alejandro
AutorGrandin, Temple
AutorMota-Rojas, Danieles_ES
AutorWhittaker, Alexandra L.es_ES
AutorCoria-Avila, Genaro A.es_ES
AutorHernandez-Avalos, Ismaeles_ES
AutorMartinez-Burnes, Julioes_ES
AutorDominguez-Oliva, Adrianaes_ES
AutorOlmos-Hernandez, Adrianaes_ES
AutorTorres-Bernal, Fabiolaes_ES
AutorReyes-Sotelo, Brendaes_ES
AutorMiranda-Cortes, Agathaes_ES
AutorCasas-Alvarado, Alejandroes_ES
AutorGrandin, Templees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fvets.2026.1878991
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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