Beliefs and preferences regarding biological treatments for severe asthma

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:45Z
Fecha de publicación2020-01-01
ResumenBackground: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers' specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as through social media. Responses from allergists and pulmonologists, both those with experience of prescribing omalizumab with (OMA/IL5) and without (OMA) experience with anti-IL5 drugs, were compared. Results: Two hundred eighty-five (285) valid questionnaires from 37 countries were analyzed. Seventy-on percent (71\%) of respondents prescribed biologics instead of oral glucocorticoids and believed that their side effects are inferior to those of Prednisone 5 mg daily. Agreement with ATS/ERS guidelines for identifying severe asthma patients was less than 50\%. Specifically, significant differences were found comparing responses between allergists and pulmonologists (Chi-square test, p < 0.05) and between OMA/IL5 and OMA groups (p < 0.05). Conclusions: Uncertainties and inconsistencies regarding the use of biological medications have been shown. The accuracy of prescribers to correctly identify asthma severity, according to guidelines criteria, is quite poor. Although a substantial majority of prescribers believe that biological drugs are safer than low dose long-term treatment with oral steroids, and that they must be used instead of oral steroids, every effort should be made to further increase awareness. Efficacy as disease modifiers, biomarkers for selecting responsive patients, timing for outcomes evaluation, and checks need to be addressed by further research. Practices and beliefs regarding the use of asthma biologics differ between the prescriber's specialty and experience; however, the latter seems more significant in determining beliefs and behavior. Tailored educational measures are needed to ensure research results are better integrated in daily practice.es_ES
Doihttps://doi.org/10.1016/j.waojou.2020.100441es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5510
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónWorld Allergy Organization Journales_ES
URL relacionadohttps://doi.org/10.1016/j.waojou.2020.100441es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteWorld Allergy Organization Journal
Palabra claveSevere asthmaes_ES
Palabra claveBiological druges_ES
Palabra claveBeliefes_ES
Palabra claveBehaviores_ES
TítuloBeliefs and preferences regarding biological treatments for severe asthmaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorBikov, Andras
AutorOguzulgen, Ipek Kivilcim
AutorBaiardini, Ilaria
AutorContoli, Marco
AutorEmelyanov, Alexander
AutorFassio, Omar
AutorCarlos Ivancevich, Juan
AutorKaidashev, Igor
AutorKowal, Krzysztof
AutorLabor, Marina
AutorLahousse, Lies
AutorMihaicuta, Stefan
AutorNovakova, Silviya
AutorPadilla Galo, Alicia
AutorSimidchiev, Alexander
AutorTiotiu, Angelica
AutorAnsotegui, Ignacio J.
AutorBernstein, Jonathan A.
AutorBoulet, Louis Philippe
AutorCanonica, Giorgio Walter
AutorDubuske, Lawrence
AutorRosario, Nelson
AutorSantus, Pierachille
AutorBraido, Fulvio
AutorInterasma Sci Network INES
AutorBikov, Andrases_ES
AutorOguzulgen, Ipek Kivilcimes_ES
AutorBaiardini, Ilariaes_ES
AutorContoli, Marcoes_ES
AutorEmelyanov, Alexanderes_ES
AutorFassio, Omares_ES
AutorCarlos Ivancevich, Juanes_ES
AutorKaidashev, Igores_ES
AutorKowal, Krzysztofes_ES
AutorLabor, Marinaes_ES
AutorLahousse, Lieses_ES
AutorMihaicuta, Stefanes_ES
AutorNovakova, Silviyaes_ES
AutorPadilla Galo, Aliciaes_ES
AutorSimidchiev, Alexanderes_ES
AutorTiotiu, Angelicaes_ES
AutorAnsotegui, Ignacio J.es_ES
AutorBernstein, Jonathan A.es_ES
AutorBoulet, Louis Philippees_ES
AutorCanonica, Giorgio Walteres_ES
AutorDubuske, Lawrencees_ES
AutorRosario, Nelsones_ES
AutorSantus, Pierachillees_ES
AutorBraido, Fulvioes_ES
AutorInterasma Sci Network INESes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
URL relacionadahttps://doi.org/10.1016/j.waojou.2020.100441
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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