Changes in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Study

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:50Z
Fecha de publicación2020-01-01
ResumenTick vaccination is an environmentally friendly alternative for tick control, pathogen infection, and transmission. Tick vaccine protection is sometimes incomplete, which may be due to problems in the stability, conformation, and activity of antibodies. This might be related to oxidative stress, but more studies are needed about the possible relationships between oxidative stress and immune function. The objective of this study was to evaluate and compare various serum biomarkers of antioxidant response and oxidative damage in cattle vaccinated with two recombinant antigens, the chimera of Subolesin- BM95 (homologue antigen of BM86)-MSP1a and BM86, and a control consisting in the adjuvant of the vaccines. Cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), trolox equivalent antioxidant capacity (TEAC), total thiol concentrations, and uric acid were evaluated in serum to determine the antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX), total oxidant status (TOS), advanced oxidation protein products (AOPP) and hydrogen peroxide (H2O2) concentrations in serum were determined. In addition, correlations between biomarkers of oxidative stress and antibody titers were evaluated. A significant decrease in all antioxidant biomarkers, with exception of thiol, and also a decrease in the oxidant markers TOS, AOPP and H2O2 was observed in cattle vaccinated with BM86, that also showed the highest antibody titers response whereas no significant differences in any of the biomarkers were detected in the Subolesin-Bm95-MSP1a and control groups. In addition, the dynamics of Cuprac and H2O2 with time showed significant differences between the groups. Although this is a pilot study and the results should be interpreted with caution and corroborated by studies involving a large number of animals, our results indicate that, in our experimental conditions, those vaccines able to induce a lower oxidative stress produce a higher concentration of antigen-specific antibodies. Overall, the results of the study provided information on the behavior of different biomarkers related to antioxidant defense, and the oxidative damage in cattle in response to vaccination.es_ES
Doihttps://doi.org/10.3390/vaccines9010005es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1800
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónVaccineses_ES
URL relacionadohttps://doi.org/10.3390/vaccines9010005es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteVaccines
TítuloChanges in Serum Biomarkers of Oxidative Stress in Cattle Vaccinated with Tick Recombinant Antigens: A Pilot Studyes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorContreras, Marinela
AutorRubio, Camila Peres
AutorFuente, José de la
AutorVillar, Margarita
AutorMerino, Octavio
AutorMosqueda, Juan
AutorCerón, José Joaquín
AutorContreras, Marinelaes_ES
AutorRubio, Camila Pereses_ES
AutorFuente, José de laes_ES
AutorVillar, Margaritaes_ES
AutorMerino, Octavioes_ES
AutorMosqueda, Juanes_ES
AutorCerón, José Joaquínes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas5es_ES
URL relacionadahttps://doi.org/10.3390/vaccines9010005
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

Files

Collections

Documentación Cientifica