Characterization of pain-related behaviors, changes in bone microarchitecture and sensory innervation induced by chronic cadmium exposure in adult mice

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:56Z
Fecha de publicación2022-01-20
ResumenBecause of the relative lack of understanding of the neurobiological mechanisms that drive toxic effects of cadmium in bone, the purpose of this study was to characterize a preclinical model of chronic cadmium exposure. Adult male C57BL/6 J mice were exposed to cadmium 25 mg/L (as CdCl2) in drinking water for 16 weeks. During this time, pain-related behaviors including hindpaw mechanical sensitivity and vertical rears were evaluated every four weeks. We assessed changes in bone microarchitecture at the femoral neck and L5 vertebra by microcomputed tomography and quantified the density of nerve fibers expressing PGP 9.5 (a pan-neuronal marker) and CGRP (a marker of sensory nerve fibers subfamily) at the femoral neck and glabrous skin of the hindpaw using immunohistochemistry. Cadmium exposure produced mechanical hypersensitivity in both hindpaws along with decreased rearing activity (surrogate for musculoskeletal-related pain) without affecting the horizontal activity (a measure of locomotor behavior) in comparison to the control group. Intraperitoneal acute treatment with morphine and gabapentin reversed pain-related behaviors in cadmium-exposed mice. Furthermore, exposure to cadmium resulted in significant trabecular bone deterioration at the femoral neck and L5 vertebra. We also observed a significant reduction in the density of both CGRP(+) and PGP 9.5(+) nerve fibers in the femoral neck, but not in the hindpaw glabrous skin, suggesting tissue-dependent neurotoxicity. This model may help in developing a mechanism-based understanding of the factors that generate and maintain musculoskeletal pain and bone loss caused by chronic cadmium exposure and in translating these findings into new therapies for treating cadmium-induced bone toxicity.es_ES
Doihttps://doi.org/10.1016/j.neuro.2022.01.009es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2662
Idiomaenes_ES
EditorialElsevier BVes_ES
RelaciónNeuroToxicologyes_ES
URL relacionadohttps://doi.org/10.1016/j.neuro.2022.01.009es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteNeuroToxicology
Palabra claveFemoral neckes_ES
Palabra claveMedicinees_ES
Palabra claveCadmiumes_ES
Palabra claveCalcitonin gene-related peptidees_ES
Palabra claveNeurotoxicityes_ES
Palabra claveAnatomyes_ES
Palabra claveOsteoporosises_ES
Palabra clavePathologyes_ES
Palabra claveInternal medicinees_ES
Palabra claveChemistryes_ES
Palabra claveToxicityes_ES
Palabra claveNeuropeptidees_ES
ClasificaciónHeavy Metal Exposure and Toxicityes_ES
TítuloCharacterization of pain-related behaviors, changes in bone microarchitecture and sensory innervation induced by chronic cadmium exposure in adult micees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorTorres-Rodríguez, Héctor Fabián
AutorGraniel-Amador, Mayra A.
AutorCruz-Camacho, Cindy J.
AutorCantú-Martínez, Alma A.
AutorMartínez-Martínez, A
AutorTorres-Rodríguez, Héctor Fabiánes_ES
AutorGraniel-Amador, Mayra A.es_ES
AutorPetricevich, Vera L.
AutorCruz-Camacho, Cindy J.es_ES
AutorCantú-Martínez, Alma A.es_ES
AutorMontes, Sergio
AutorMartínez-Martínez, Aes_ES
AutorPetricevich, Vera L.es_ES
AutorCastañeda‐Corral, Gabriela
AutorMontes, Sergioes_ES
AutorCastañeda‐Corral, Gabrielaes_ES
AutorJiménez‐Andrade, Juan Miguel
AutorJiménez‐Andrade, Juan Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas99-109es_ES
URL relacionadahttps://doi.org/10.1016/j.neuro.2022.01.009
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen89es_ES

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