Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:31Z
Fecha de publicación2024-01-01
ResumenCrosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential therapeutic target for bone metastasis. Although the role of peripheral nerves in cancer progression has been appreciated, little is known regarding cancer/sensory nerve crosstalk and its contribution to bone metastasis and associated pain. In this study, we revealed that the cancer/sensory nerve crosstalk plays a crucial role in bone metastatic progression. We found that (i) periosteal sensory nerves expressing calcitonin gene-related peptide (CGRP) are enriched in mice with bone metastasis; (ii) cancer patients with bone metastasis have elevated CGRP serum levels; (iii) bone metastatic patient tumor samples express elevated calcitonin receptor-like receptor (CRLR, a CGRP receptor component); (iv) higher CRLR levels in cancer patients are negatively correlated with recurrence-free survival; (v) CGRP induces cancer cell proliferation through the CRLR/p38/HSP27 pathway; and (vi) blocking sensory neuron-derived CGRP reduces cancer cell proliferation in vitro and bone metastatic progression in vivo. This suggests that CGRP-expressing sensory nerves are involved in bone metastatic progression and that the CGRP/CRLR axis may serve as a potential therapeutic target for bone metastasis.es_ES
Doihttps://doi.org/10.26508/lsa.202302041es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5329
Idiomaenes_ES
EditorialLIFE SCIENCE ALLIANCE LLCes_ES
RelaciónLife Science Alliancees_ES
URL relacionadohttps://doi.org/10.26508/lsa.202302041es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteLife Science Alliance
TítuloCrosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progressiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPark, Sun H.
AutorTsuzuki, Shunsuke
AutorContino, Kelly F.
AutorOllodart, Jenna
AutorEber, Matthew R.
AutorYu, Yang
AutorSteele, Laiton R.
AutorInaba, Hiroyuki
AutorKamata, Yuko
AutorKimura, Takahiro
AutorColeman, Ilsa
AutorNelson, Peter S.
AutorMunoz-Islas, Enriqueta
AutorJimenez-Andrade, Juan Miguel
AutorMartin, Thomas J.
AutorMackenzie, Kimberly D.
AutorStratton, Jennifer R.
AutorHsu, Fang-Chi
AutorPeters, Christopher M.
AutorShiozawa, Yusuke
AutorPark, Sun H.es_ES
AutorTsuzuki, Shunsukees_ES
AutorContino, Kelly F.es_ES
AutorOllodart, Jennaes_ES
AutorEber, Matthew R.es_ES
AutorYu, Yanges_ES
AutorSteele, Laiton R.es_ES
AutorInaba, Hiroyukies_ES
AutorKamata, Yukoes_ES
AutorKimura, Takahiroes_ES
AutorColeman, Ilsaes_ES
AutorNelson, Peter S.es_ES
AutorMunoz-Islas, Enriquetaes_ES
AutorJimenez-Andrade, Juan Migueles_ES
AutorMartin, Thomas J.es_ES
AutorMackenzie, Kimberly D.es_ES
AutorStratton, Jennifer R.es_ES
AutorHsu, Fang-Chies_ES
AutorPeters, Christopher M.es_ES
AutorShiozawa, Yusukees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número12es_ES
URL relacionadahttps://doi.org/10.26508/lsa.202302041
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen7es_ES

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