Genetic Elements That Contribute to Antibiotic Resistance in Bacteria of Clinical Importance

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:26Z
Fecha de publicación2026-01-01
ResumenAntimicrobial resistance (AMR) poses a severe threat to global health by limiting treatment options and increasing clinical and economic burdens. This review synthesizes evidence showing that resistance evolution is strongly shaped by antibiotic pressure, leading to the accumulation of adaptive mutations, activation of efflux systems, and widespread dissemination of resistance determinants across clinical, animal, and environmental settings. We highlight recent genomic, metagenomic, and structural findings that elucidate the molecular basis of AMR, with particular emphasis on horizontal gene transfer mediated by mobile genetic elements such as plasmids, integrons, and transposons. Analyses across One Health interfaces reveal extensive sharing of antimicrobial resistance genes among humans, livestock, and environmental reservoirs, identifying Enterobacteriaceae and ESKAPE pathogens as key hubs of resistance dissemination. Special focus is placed on Acinetobacter baumannii, where phylogenetic and three-dimensional structural analyses of class D β-lactamases OXA-23 and OXA-24/40 demonstrate a conserved catalytic framework coupled with substantial sequence and conformational variability. These structural differences likely influence carbapenem specificity and resistance levels. Collectively, the findings underscore how genetic diversity, mobile elements, and structural adaptation converge to drive AMR, reinforcing the need for integrated genomic and structural approaches to guide surveillance and antimicrobial development.es_ES
Doihttps://doi.org/10.3390/bacteria5010014es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2396
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónBacteriaes_ES
URL relacionadohttps://doi.org/10.3390/bacteria5010014es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBacteria
TítuloGenetic Elements That Contribute to Antibiotic Resistance in Bacteria of Clinical Importancees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAyil-Gutiérrez, Benjamín Abraham
AutorAcosta-Cruz, Erika
AutorBello-López, Juan Manuel
AutorVásquez-Martínez, Yesseny
AutorMartin, Marcelo Cortez-San
AutorSánchez-Teyer, Lorenzo Felipe
AutorRodríguez-Zapata, Luis Carlos
AutorTamayo-Ordoñez, Francisco Alberto
AutorCázares-Sánchez, Esmeralda
AutorRamos-García, Víctor Hugo
AutorSánchez-López, Eric
AutorVillanueva-Alonzo, Hernan de Jesús
AutorBocanegra-García, Virgilio
AutorMartínez-Montoya, Humberto
AutorDíaz-Palafox, Grethel
AutorGarcía-Castillo, María José
AutorTamayo-Ordoñez, María Concepción
AutorTamayo-Ordoñez, Yahaira de Jesús
AutorAyil-Gutiérrez, Benjamín Abrahames_ES
AutorAcosta-Cruz, Erikaes_ES
AutorBello-López, Juan Manueles_ES
AutorVásquez-Martínez, Yessenyes_ES
AutorMartin, Marcelo Cortez-Sanes_ES
AutorSánchez-Teyer, Lorenzo Felipees_ES
AutorRodríguez-Zapata, Luis Carloses_ES
AutorTamayo-Ordoñez, Francisco Albertoes_ES
AutorCázares-Sánchez, Esmeraldaes_ES
AutorRamos-García, Víctor Hugoes_ES
AutorSánchez-López, Erices_ES
AutorVillanueva-Alonzo, Hernan de Jesúses_ES
AutorBocanegra-García, Virgilioes_ES
AutorMartínez-Montoya, Humbertoes_ES
AutorDíaz-Palafox, Gretheles_ES
AutorGarcía-Castillo, María Josées_ES
AutorTamayo-Ordoñez, María Concepciónes_ES
AutorTamayo-Ordoñez, Yahaira de Jesúses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas14es_ES
URL relacionadahttps://doi.org/10.3390/bacteria5010014
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen5es_ES

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