Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases?

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:40Z
Fecha de publicación2020-01-01
ResumenParasitic diseases, caused by helminths (ascariasis, hookworm, trichinosis, and schistosomiasis) and protozoa (chagas, leishmaniasis, and amebiasis), are considered a serious public health problem in developing countries. Additionally, there is a limited arsenal of anti-parasitic drugs in the current pipeline and growing drug resistance. Therefore, there is a clear need for the discovery and development of new compounds that can compete and replace these drugs that have been controlling parasitic infections over the last decades. However, this approach is highly resource- intensive, expensive and time-consuming. Accordingly, a drug repositioning strategy of the existing drugs or drug-like molecules with known pharmacokinetics and safety profiles is alternatively being used as a fast approach towards the identification of new treatments. The artemisinins, mefloquine, tribendimidine, oxantel pamoate and doxycycline for the treatment of helminths, and posaconazole and hydroxymethylnitrofurazone for the treatment of protozoa are promising candidates. Therefore, traditional antiprotozoal drugs, which were developed in some cases decades ago, are a valid solution. Herein, we review the current status of traditional anti-helminthic and antiprotozoal drugs in terms of drug targets, mode of action, doses, adverse effects, and parasite resistance to define their suitability for repurposing strategies. Current antiparasitic drugs are not only still viable for the treatment of helminth and protozoan infections but are also important candidates for new pharmacological treatments.es_ES
Doihttps://doi.org/10.2174/0929867326666190628163633es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1651
Idiomaeses_ES
EditorialBentham Science Publishers Ltd.es_ES
RelaciónCurrent Medicinal Chemistryes_ES
URL relacionadohttps://doi.org/10.2174/0929867326666190628163633es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCurrent Medicinal Chemistry
TítuloOld Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases?es_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCortez-Maya, Sandra
AutorMoreno-Herrera, Antonio
AutorPalos, Isidro
AutorRivera, Gildardo
AutorCortez-Maya, Sandraes_ES
AutorMoreno-Herrera, Antonioes_ES
AutorPalos, Isidroes_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número32es_ES
Rango de páginas5403-5428es_ES
URL relacionadahttps://doi.org/10.2174/0929867326666190628163633
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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